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Differential Effects of Drug Interventions and Dietary Lifestyle in Developing Type 2 Diabetes and Complications: A Systems Biology Analysis in LDLr−/− Mice
Excess caloric intake leads to metabolic overload and is associated with development of type 2 diabetes (T2DM). Current disease management concentrates on risk factors of the disease such as blood glucose, however with limited success. We hypothesize that normalizing blood glucose levels by itself i...
Autores principales: | Radonjic, Marijana, Wielinga, Peter Y., Wopereis, Suzan, Kelder, Thomas, Goelela, Varshna S., Verschuren, Lars, Toet, Karin, van Duyvenvoorde, Wim, van der Werff van der Vat, Bianca, Stroeve, Johanna H. M., Cnubben, Nicole, Kooistra, Teake, van Ommen, Ben, Kleemann, Robert |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574110/ https://www.ncbi.nlm.nih.gov/pubmed/23457508 http://dx.doi.org/10.1371/journal.pone.0056122 |
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