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The Effect of Route of Administration in Thymoquinone Toxicity in Male and Female Rats

The maximum tolerated dose for intraperitoneal injection and oral ingestion of thymoquinone was determined in male and female Wistar rats. A range of dose levels of thymoquinone: 20, 30 and 40 mg/kg body weight for intraperitoneal injection and 200, 300 and 500 mg/kg body weight for oral ingestion w...

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Autor principal: AbuKhader, M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574528/
https://www.ncbi.nlm.nih.gov/pubmed/23440704
http://dx.doi.org/10.4103/0250-474X.106060
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author AbuKhader, M. M.
author_facet AbuKhader, M. M.
author_sort AbuKhader, M. M.
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description The maximum tolerated dose for intraperitoneal injection and oral ingestion of thymoquinone was determined in male and female Wistar rats. A range of dose levels of thymoquinone: 20, 30 and 40 mg/kg body weight for intraperitoneal injection and 200, 300 and 500 mg/kg body weight for oral ingestion were tested for acute toxicity in rats. The results showed that the maximum tolerated dose for intraperitoneal injection was 22.5 mg/kg in male rats and 15 mg/kg in females, whereas for oral ingestion it was 250 mg/kg in both male and female rats. There were different signs of toxicity shown in rats which received intraperitoneal injection from those that received oral ingestion of thymoquinone. Rats which received intraperitoneal injection of thymoquinone showed toxicity signs which were related to acute pancreatitis. Meanwhile, rats which received oral ingestion of thymoquinone showed transient toxicity signs. Two deaths were reported at dose of 500 mg/kg as a result of bowel obstruction complications. The data presented in this study indicate that the route of administration of thymoquinone could have an influence on thymoquinone toxicity outcome in both genders.
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spelling pubmed-35745282013-02-22 The Effect of Route of Administration in Thymoquinone Toxicity in Male and Female Rats AbuKhader, M. M. Indian J Pharm Sci Research Paper The maximum tolerated dose for intraperitoneal injection and oral ingestion of thymoquinone was determined in male and female Wistar rats. A range of dose levels of thymoquinone: 20, 30 and 40 mg/kg body weight for intraperitoneal injection and 200, 300 and 500 mg/kg body weight for oral ingestion were tested for acute toxicity in rats. The results showed that the maximum tolerated dose for intraperitoneal injection was 22.5 mg/kg in male rats and 15 mg/kg in females, whereas for oral ingestion it was 250 mg/kg in both male and female rats. There were different signs of toxicity shown in rats which received intraperitoneal injection from those that received oral ingestion of thymoquinone. Rats which received intraperitoneal injection of thymoquinone showed toxicity signs which were related to acute pancreatitis. Meanwhile, rats which received oral ingestion of thymoquinone showed transient toxicity signs. Two deaths were reported at dose of 500 mg/kg as a result of bowel obstruction complications. The data presented in this study indicate that the route of administration of thymoquinone could have an influence on thymoquinone toxicity outcome in both genders. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3574528/ /pubmed/23440704 http://dx.doi.org/10.4103/0250-474X.106060 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
AbuKhader, M. M.
The Effect of Route of Administration in Thymoquinone Toxicity in Male and Female Rats
title The Effect of Route of Administration in Thymoquinone Toxicity in Male and Female Rats
title_full The Effect of Route of Administration in Thymoquinone Toxicity in Male and Female Rats
title_fullStr The Effect of Route of Administration in Thymoquinone Toxicity in Male and Female Rats
title_full_unstemmed The Effect of Route of Administration in Thymoquinone Toxicity in Male and Female Rats
title_short The Effect of Route of Administration in Thymoquinone Toxicity in Male and Female Rats
title_sort effect of route of administration in thymoquinone toxicity in male and female rats
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574528/
https://www.ncbi.nlm.nih.gov/pubmed/23440704
http://dx.doi.org/10.4103/0250-474X.106060
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