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Design and Evaluation of Microemulsion Gel System of Nadifloxacin
Topical microemulsion systems for the antiacne agent, nadifloxacin were designed and developed to overcome the problems associated with the cutaneous delivery due to poor water solubility. The solubility of nadifloxacin in oils, surfactants and cosurfactants was evaluated to screen the components of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574534/ https://www.ncbi.nlm.nih.gov/pubmed/23439454 http://dx.doi.org/10.4103/0250-474X.106066 |
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author | Shinde, Ujwala Pokharkar, Sharda Modani, Sheela |
author_facet | Shinde, Ujwala Pokharkar, Sharda Modani, Sheela |
author_sort | Shinde, Ujwala |
collection | PubMed |
description | Topical microemulsion systems for the antiacne agent, nadifloxacin were designed and developed to overcome the problems associated with the cutaneous delivery due to poor water solubility. The solubility of nadifloxacin in oils, surfactants and cosurfactants was evaluated to screen the components of the microemulsion. Various surfactants and cosurfactants were screened for their ability to emulsify the selected oily phase. The pseudoternary diagrams were constructed to identify the area of microemulsion existence. The influence of k(m) (surfactant/cosurfactant) ratio on the microemulsion existence region was determined and optimum systems were designed. The systems were assessed for drug-loading efficiency and characterised for optical birefringence, pH and refractive index, robustness to dilution, globule size, drug content and thermodynamic stability. Optimised microemulsion systems were formulated into gel form and evaluated for viscosity, spreadability, drug content, ex vivo skin permeation and antibacterial activity. The maximum solubility of nadifloxacin in the microemulsion system was found to be 0.25%. The nadifloxacin microemulsions had a small and uniform globule size (67.3-121.23 nm). The stability results revealed that all formulations showed a stable globule size and the polydispersity index under stress conditions. Incorporation of nadifloxacin in microemulsion gel increased the ex vivo skin permeation and antibacterial activity when compared to marketed cream. |
format | Online Article Text |
id | pubmed-3574534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-35745342013-02-22 Design and Evaluation of Microemulsion Gel System of Nadifloxacin Shinde, Ujwala Pokharkar, Sharda Modani, Sheela Indian J Pharm Sci Research Paper Topical microemulsion systems for the antiacne agent, nadifloxacin were designed and developed to overcome the problems associated with the cutaneous delivery due to poor water solubility. The solubility of nadifloxacin in oils, surfactants and cosurfactants was evaluated to screen the components of the microemulsion. Various surfactants and cosurfactants were screened for their ability to emulsify the selected oily phase. The pseudoternary diagrams were constructed to identify the area of microemulsion existence. The influence of k(m) (surfactant/cosurfactant) ratio on the microemulsion existence region was determined and optimum systems were designed. The systems were assessed for drug-loading efficiency and characterised for optical birefringence, pH and refractive index, robustness to dilution, globule size, drug content and thermodynamic stability. Optimised microemulsion systems were formulated into gel form and evaluated for viscosity, spreadability, drug content, ex vivo skin permeation and antibacterial activity. The maximum solubility of nadifloxacin in the microemulsion system was found to be 0.25%. The nadifloxacin microemulsions had a small and uniform globule size (67.3-121.23 nm). The stability results revealed that all formulations showed a stable globule size and the polydispersity index under stress conditions. Incorporation of nadifloxacin in microemulsion gel increased the ex vivo skin permeation and antibacterial activity when compared to marketed cream. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3574534/ /pubmed/23439454 http://dx.doi.org/10.4103/0250-474X.106066 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Shinde, Ujwala Pokharkar, Sharda Modani, Sheela Design and Evaluation of Microemulsion Gel System of Nadifloxacin |
title | Design and Evaluation of Microemulsion Gel System of Nadifloxacin |
title_full | Design and Evaluation of Microemulsion Gel System of Nadifloxacin |
title_fullStr | Design and Evaluation of Microemulsion Gel System of Nadifloxacin |
title_full_unstemmed | Design and Evaluation of Microemulsion Gel System of Nadifloxacin |
title_short | Design and Evaluation of Microemulsion Gel System of Nadifloxacin |
title_sort | design and evaluation of microemulsion gel system of nadifloxacin |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574534/ https://www.ncbi.nlm.nih.gov/pubmed/23439454 http://dx.doi.org/10.4103/0250-474X.106066 |
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