A Novel Peptide-Based SILAC Method to Identify the Posttranslational Modifications Provides Evidence for Unconventional Ubiquitination in the ER-Associated Degradation Pathway

The endoplasmic reticulum-associated degradation (ERAD) pathway is responsible for disposing misfolded proteins from the endoplasmic reticulum by inducing their ubiquitination and degradation. Ubiquitination is conventionally observed on lysine residues and has been demonstrated on cysteine residues...

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Detalles Bibliográficos
Autores principales: Anania, Veronica G., Bustos, Daisy J., Lill, Jennie R., Kirkpatrick, Donald S., Coscoy, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574754/
https://www.ncbi.nlm.nih.gov/pubmed/23431445
http://dx.doi.org/10.1155/2013/857918

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