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Exploring the temporal development of childhood IgE profiles to allergen components
BACKGROUND: Children often develop allergies that may or not persist into adulthood. Although the different allergic symptoms over time have been well documented, the underlying pattern of sensitization to various proteins and subsequent allergy development is unexplored. The aim was to study the se...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574828/ https://www.ncbi.nlm.nih.gov/pubmed/23254184 http://dx.doi.org/10.1186/2045-7022-2-24 |
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author | Önell, Annica Hjälle, Lisbeth Borres, Magnus P |
author_facet | Önell, Annica Hjälle, Lisbeth Borres, Magnus P |
author_sort | Önell, Annica |
collection | PubMed |
description | BACKGROUND: Children often develop allergies that may or not persist into adulthood. Although the different allergic symptoms over time have been well documented, the underlying pattern of sensitization to various proteins and subsequent allergy development is unexplored. The aim was to study the sensitization pattern to allergen components over time from infancy to adulthood in a group of infants with heredity for allergic diseases. METHODS: IgE profiles were monitored in a group of 67 children from 6 months to 18 years using a microarray chip (ImmunoCAP® ISAC) containing 103 allergen components derived from 47 allergen sources. The chip IgE profile was compared with clinical history, skin prick test results and diagnoses (atopic dermatitis, asthma and allergic rhinoconjunctivitis) at each time point for each child. RESULTS: IgE profiles were unique for each child and showed broad agreement with the results of skin prick tests and doctors’ diagnoses. In addition, close examination of the IgE profiles often revealed early indication of subsequent allergies. IgE profiles also facilitated the examination of cross-reactivity contra co-sensitization, thereby greatly enhancing the possibility for managing patients. CONCLUSION: This explorative description indicates that sensitization pattern to allergen components differs over time as well as among allergic individuals when examined with microarray technology. |
format | Online Article Text |
id | pubmed-3574828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35748282013-02-18 Exploring the temporal development of childhood IgE profiles to allergen components Önell, Annica Hjälle, Lisbeth Borres, Magnus P Clin Transl Allergy Research BACKGROUND: Children often develop allergies that may or not persist into adulthood. Although the different allergic symptoms over time have been well documented, the underlying pattern of sensitization to various proteins and subsequent allergy development is unexplored. The aim was to study the sensitization pattern to allergen components over time from infancy to adulthood in a group of infants with heredity for allergic diseases. METHODS: IgE profiles were monitored in a group of 67 children from 6 months to 18 years using a microarray chip (ImmunoCAP® ISAC) containing 103 allergen components derived from 47 allergen sources. The chip IgE profile was compared with clinical history, skin prick test results and diagnoses (atopic dermatitis, asthma and allergic rhinoconjunctivitis) at each time point for each child. RESULTS: IgE profiles were unique for each child and showed broad agreement with the results of skin prick tests and doctors’ diagnoses. In addition, close examination of the IgE profiles often revealed early indication of subsequent allergies. IgE profiles also facilitated the examination of cross-reactivity contra co-sensitization, thereby greatly enhancing the possibility for managing patients. CONCLUSION: This explorative description indicates that sensitization pattern to allergen components differs over time as well as among allergic individuals when examined with microarray technology. BioMed Central 2012-12-19 /pmc/articles/PMC3574828/ /pubmed/23254184 http://dx.doi.org/10.1186/2045-7022-2-24 Text en Copyright ©2012 Önell et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Önell, Annica Hjälle, Lisbeth Borres, Magnus P Exploring the temporal development of childhood IgE profiles to allergen components |
title | Exploring the temporal development of childhood IgE profiles to allergen components |
title_full | Exploring the temporal development of childhood IgE profiles to allergen components |
title_fullStr | Exploring the temporal development of childhood IgE profiles to allergen components |
title_full_unstemmed | Exploring the temporal development of childhood IgE profiles to allergen components |
title_short | Exploring the temporal development of childhood IgE profiles to allergen components |
title_sort | exploring the temporal development of childhood ige profiles to allergen components |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574828/ https://www.ncbi.nlm.nih.gov/pubmed/23254184 http://dx.doi.org/10.1186/2045-7022-2-24 |
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