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Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism

c-Src is a non-receptor tyrosine kinase involved in numerous signal transduction pathways. The kinase, SH3 and SH2 domains of c-Src are attached to the membrane-anchoring SH4 domain through the flexible Unique domain. Here we show intra- and intermolecular interactions involving the Unique and SH3 d...

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Detalles Bibliográficos
Autores principales:	Pérez, Yolanda, Maffei, Mariano, Igea, Ana, Amata, Irene, Gairí, Margarida, Nebreda, Angel R., Bernadó, Pau, Pons, Miquel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575015/ https://www.ncbi.nlm.nih.gov/pubmed/23416516 http://dx.doi.org/10.1038/srep01295

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