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Role of mutations in the cellular internalization of amyloidogenic light chains into cardiomyocytes

Light chain (AL) amyloidosis is characterized by the misfolding of immunoglobulin light chains, accumulating as amyloid fibrils in vital organs. Multiple reports have indicated that amyloidogenic light chains internalize into a variety of cell types, but these studies used urine-derived proteins wit...

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Detalles Bibliográficos
Autores principales:	Levinson, Rebecca T., Olatoye, Oludare O., Randles, Edward G., Howell, Kyle G., DiCostanzo, Ara Celi, Ramirez-Alvarado, Marina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575045/ https://www.ncbi.nlm.nih.gov/pubmed/23417147 http://dx.doi.org/10.1038/srep01278

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