Cargando…

Renal biopsy pathology in a cohort of patients from southwest Sydney with clinically diagnosed systemic lupus erythematosus

PURPOSE: The pathological manifestations in the kidneys in systemic lupus erythematosus (SLE) are commonly known as lupus nephritis. We have studied the pathological changes in renal biopsies from 59 cases of clinically diagnosed SLE obtained over a 15-year period from a racially diverse population...

Descripción completa

Detalles Bibliográficos
Autores principales: Yong, Jim LC, Killingsworth, Murray C, Lai, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575160/
https://www.ncbi.nlm.nih.gov/pubmed/23431084
http://dx.doi.org/10.2147/IJNRD.S34357
_version_ 1782259668968538112
author Yong, Jim LC
Killingsworth, Murray C
Lai, Ken
author_facet Yong, Jim LC
Killingsworth, Murray C
Lai, Ken
author_sort Yong, Jim LC
collection PubMed
description PURPOSE: The pathological manifestations in the kidneys in systemic lupus erythematosus (SLE) are commonly known as lupus nephritis. We have studied the pathological changes in renal biopsies from 59 cases of clinically diagnosed SLE obtained over a 15-year period from a racially diverse population in the Sydney metropolitan area. Our aim was to see if there was any regional variation in the morphological changes. METHODS: Renal biopsy changes were assessed by routine light, immunofluorescence, and electron microscopy. We used the modified 1974 World Health Organization classification of lupus nephritis to classify cases into six classes. Disease severity was assessed by age, sex, and across racial groups, including Caucasian, Asian, Middle Eastern, Mediterranean, Indian subcontinental, South American, and Pacific Islander. RESULTS: Our analysis showed that cases of lupus nephritis contributed 5.4% of our total renal biopsies examined over a 15-year period. The overall incidence of biopsy-proven cases was 0.49 per 100,000 per year. The ages of our patients ranged from 10 to 79 years, with most below 50 years of age. A female to male ratio was determined to be 4.4:1. There was no relationship to ethnicity, nor was there a relationship between any of these parameters and the class or severity of disease. CONCLUSION: Renal biopsy with multimodal morphological and immunohistochemical analysis remains the gold standard for diagnosis and determination of the level of disease in lupus nephritis. Based on this approach we have identified an incidence rate for southwest Sydney that is slightly higher but comparable to that found in a similar study from the United Kingdom. We also found that there was no relationship between sex, race, or age and severity of disease.
format Online
Article
Text
id pubmed-3575160
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-35751602013-02-21 Renal biopsy pathology in a cohort of patients from southwest Sydney with clinically diagnosed systemic lupus erythematosus Yong, Jim LC Killingsworth, Murray C Lai, Ken Int J Nephrol Renovasc Dis Original Research PURPOSE: The pathological manifestations in the kidneys in systemic lupus erythematosus (SLE) are commonly known as lupus nephritis. We have studied the pathological changes in renal biopsies from 59 cases of clinically diagnosed SLE obtained over a 15-year period from a racially diverse population in the Sydney metropolitan area. Our aim was to see if there was any regional variation in the morphological changes. METHODS: Renal biopsy changes were assessed by routine light, immunofluorescence, and electron microscopy. We used the modified 1974 World Health Organization classification of lupus nephritis to classify cases into six classes. Disease severity was assessed by age, sex, and across racial groups, including Caucasian, Asian, Middle Eastern, Mediterranean, Indian subcontinental, South American, and Pacific Islander. RESULTS: Our analysis showed that cases of lupus nephritis contributed 5.4% of our total renal biopsies examined over a 15-year period. The overall incidence of biopsy-proven cases was 0.49 per 100,000 per year. The ages of our patients ranged from 10 to 79 years, with most below 50 years of age. A female to male ratio was determined to be 4.4:1. There was no relationship to ethnicity, nor was there a relationship between any of these parameters and the class or severity of disease. CONCLUSION: Renal biopsy with multimodal morphological and immunohistochemical analysis remains the gold standard for diagnosis and determination of the level of disease in lupus nephritis. Based on this approach we have identified an incidence rate for southwest Sydney that is slightly higher but comparable to that found in a similar study from the United Kingdom. We also found that there was no relationship between sex, race, or age and severity of disease. Dove Medical Press 2013-02-13 /pmc/articles/PMC3575160/ /pubmed/23431084 http://dx.doi.org/10.2147/IJNRD.S34357 Text en © 2013 Yong et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Yong, Jim LC
Killingsworth, Murray C
Lai, Ken
Renal biopsy pathology in a cohort of patients from southwest Sydney with clinically diagnosed systemic lupus erythematosus
title Renal biopsy pathology in a cohort of patients from southwest Sydney with clinically diagnosed systemic lupus erythematosus
title_full Renal biopsy pathology in a cohort of patients from southwest Sydney with clinically diagnosed systemic lupus erythematosus
title_fullStr Renal biopsy pathology in a cohort of patients from southwest Sydney with clinically diagnosed systemic lupus erythematosus
title_full_unstemmed Renal biopsy pathology in a cohort of patients from southwest Sydney with clinically diagnosed systemic lupus erythematosus
title_short Renal biopsy pathology in a cohort of patients from southwest Sydney with clinically diagnosed systemic lupus erythematosus
title_sort renal biopsy pathology in a cohort of patients from southwest sydney with clinically diagnosed systemic lupus erythematosus
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575160/
https://www.ncbi.nlm.nih.gov/pubmed/23431084
http://dx.doi.org/10.2147/IJNRD.S34357
work_keys_str_mv AT yongjimlc renalbiopsypathologyinacohortofpatientsfromsouthwestsydneywithclinicallydiagnosedsystemiclupuserythematosus
AT killingsworthmurrayc renalbiopsypathologyinacohortofpatientsfromsouthwestsydneywithclinicallydiagnosedsystemiclupuserythematosus
AT laiken renalbiopsypathologyinacohortofpatientsfromsouthwestsydneywithclinicallydiagnosedsystemiclupuserythematosus