Cargando…

In vivo evaluation of a conjugated poly(lactide-ethylene glycol) nanoparticle depot formulation for prolonged insulin delivery in the diabetic rabbit model

Poly(ethylene glycol) (PEG) and polylactic acid (PLA)-based copolymeric nanoparticles were synthesized and investigated as a carrier for prolonged delivery of insulin via the parenteral route. Insulin loading was simultaneously achieved with particle synthesis using a double emulsion solvent evapora...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tomar, Lomas, Tyagi, Charu, Kumar, Manoj, Kumar, Pradeep, Singh, Harpal, Choonara, Yahya E, Pillay, Viness
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575164/ https://www.ncbi.nlm.nih.gov/pubmed/23429428 http://dx.doi.org/10.2147/IJN.S38011

Ejemplares similares

Macroporous chitosan/methoxypoly(ethylene glycol) based cryosponges with unique morphology for tissue engineering applications
por: Kumar, Pradeep, et al.
Publicado: (2021)

Overview of the role of nanotechnological innovations in the detection and treatment of solid tumors
por: Frank, Derusha, et al.
Publicado: (2014)

Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy
por: Hoosain, Famida G., et al.
Publicado: (2015)

Integration of Biosensors and Drug Delivery Technologies for Early Detection and Chronic Management of Illness
por: Ngoepe, Mpho, et al.
Publicado: (2013)

The Design of Poly(lactide-co-glycolide) Nanocarriers for Medical Applications
por: Essa, Divesha, et al.
Publicado: (2020)

In silico analytico‐mathematical interpretation of biopolymeric assemblies: Quantification of energy surfaces and molecular attributes via atomistic simulations
por: Kumar, Pradeep, et al.
Publicado: (2018)

In Silico Affinity Profiling of Neuroactive Polyphenols for Post-Traumatic Calpain Inactivation: A Molecular Docking and Atomistic Simulation Sensitivity Analysis
por: Kumar, Pradeep, et al.
Publicado: (2014)

“On-The-Spot” Arresting of Chondroitin Sulphate Proteoglycans: Implications for Ovarian Adenocarcinoma Recognition and Intervention
por: Pradeep, Priyamvada, et al.
Publicado: (2016)

Prolonged Delivery of Ciprofloxacin and Diclofenac Sodium from a Polymeric Fibre Device for the Treatment of Peridontal Disease
por: Johnston, Deanne, et al.
Publicado: (2013)

Repositioning N-Acetylcysteine (NAC): NAC-Loaded Electrospun Drug Delivery Scaffolding for Potential Neural Tissue Engineering Application
por: Mahumane, Gillian D., et al.
Publicado: (2020)

Functionalized, Vertically Super-Aligned Multiwalled Carbon Nanotubes for Potential Biomedical Applications
por: Komane, Patrick P., et al.
Publicado: (2020)

3D Printed, PVA–PAA Hydrogel Loaded-Polycaprolactone Scaffold for the Delivery of Hydrophilic In-Situ Formed Sodium Indomethacin
por: Govender, Mershen, et al.
Publicado: (2018)

Synthesis and Properties of CurNQ for the Theranostic Application in Ovarian Cancer Intervention
por: Freidus, Lara G., et al.
Publicado: (2020)

In Vitro and In Silico Analyses of Nicotine Release from a Gelisphere-Loaded Compressed Polymeric Matrix for Potential Parkinson’s Disease Interventions
por: Kumar, Pradeep, et al.
Publicado: (2018)

The Influence of Lyophilized EmuGel Silica Microspheres on the Physicomechanical Properties, In Vitro Bioactivity and Biodegradation of a Novel Ciprofloxacin-Loaded PCL/PAA Scaffold
por: Mabrouk, Mostafa, et al.
Publicado: (2016)

Stimuli-Responsive Polymeric Systems for Controlled Protein and Peptide Delivery: Future Implications for Ocular Delivery
por: Mahlumba, Pakama, et al.
Publicado: (2016)

Artificial, Triple-Layered, Nanomembranous Wound Patch for Potential Diabetic Foot Ulcer Intervention
por: Mabrouk, Mostafa, et al.
Publicado: (2018)

Neo-Geometric Copper Nanocrystals by Competitive, Dual Surfactant-Mediated Facet Adsorption Controlling Skin Permeation
por: Murugan, Karmani, et al.
Publicado: (2016)

Synthesis of Cerium Oxide Nanoparticles Using Various Methods: Implications for Biomedical Applications
por: Nyoka, Mpumelelo, et al.
Publicado: (2020)

Nanotechnology and Glycosaminoglycans: Paving the Way Forward for Ovarian Cancer Intervention
por: Hoosen, Yasar, et al.
Publicado: (2018)

A Review of Nanotechnology for Targeted Anti-schistosomal Therapy
por: Adekiya, Tayo Alex, et al.
Publicado: (2020)

Three-Dimensional Printability of an ECM-Based Gelatin Methacryloyl (GelMA) Biomaterial for Potential Neuroregeneration
por: Da Silva, Kate, et al.
Publicado: (2021)

Hypothesis: apo‐lactoferrin–Galantamine Proteo‐alkaloid Conjugate for Alzheimer's disease Intervention
por: Akilo, Olufemi D., et al.
Publicado: (2018)

In Silico Theoretical Molecular Modeling for Alzheimer’s Disease: The Nicotine-Curcumin Paradigm in Neuroprotection and Neurotherapy
por: Kumar, Pradeep, et al.
Publicado: (2011)

A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury
por: Ramburrun, Poornima, et al.
Publicado: (2014)

Novel High-Viscosity Polyacrylamidated Chitosan for Neural Tissue Engineering: Fabrication of Anisotropic Neurodurable Scaffold via Molecular Disposition of Persulfate-Mediated Polymer Slicing and Complexation
por: Kumar, Pradeep, et al.
Publicado: (2012)

Parameters and characteristics governing cellular internalization and trans-barrier trafficking of nanostructures
por: Murugan, Karmani, et al.
Publicado: (2015)

A Hybrid Methacrylate-Sodium Carboxymethylcellulose Interpolyelectrolyte Complex: Rheometry and in Silico Disposition for Controlled Drug Release
por: Ngwuluka, Ndidi Chinyelu, et al.
Publicado: (2013)

Non-Isothermal Crystallization Kinetics of Poly(Ethylene Glycol)–Poly(l-Lactide) Diblock Copolymer and Poly(Ethylene Glycol) Homopolymer via Fast-Scan Chip-Calorimeter
por: Chen, Dejia, et al.
Publicado: (2021)

Preparation and Evaluation of Poly(Ethylene Glycol)–Poly(Lactide) Micelles as Nanocarriers for Oral Delivery of Cyclosporine A
por: Zhang, Yanhui, et al.
Publicado: (2010)

Pranoprofen Nanoparticles With Poly(L-Lactide)-b-Poly(Ethylene Glycol)-b-Poly(L-Lactide) as the Matrix Toward Improving Ocular Anti-inflammation
por: Luo, Yang, et al.
Publicado: (2020)

A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery
por: Khan, Zaheeda, et al.
Publicado: (2013)

Drug Delivery Strategies for Antivirals against Hepatitis B Virus
por: Singh, Latavia, et al.
Publicado: (2018)

Biodegradable nanoparticles of methoxy poly(ethylene glycol)-b-poly( d, l-lactide)/methoxy poly(ethylene glycol)- b-poly(ϵ-caprolactone) blends for drug delivery
por: Baimark, Yodthong, et al.
Publicado: (2012)

Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables
por: Cagnon, Marie-Emérentienne, et al.
Publicado: (2021)

An Injectable Nano-Enabled Thermogel to Attain Controlled Delivery of p11 Peptide for the Potential Treatment of Ocular Angiogenic Disorders of the Posterior Segment
por: du Toit, Lisa Claire, et al.
Publicado: (2021)

Improvement in Thermal Stability of Flexible Poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) Bioplastic by Blending with Native Cassava Starch
por: Srisuwan, Yaowalak, et al.
Publicado: (2022)

Phase Morphology, Mechanical, and Thermal Properties of Calcium Carbonate-Reinforced Poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) Bioplastics
por: Srihanam, Prasong, et al.
Publicado: (2023)

Poly(Ethylene Glycol)-b-Poly(D,L-Lactide) Nanoparticles as Potential Carriers for Anticancer Drug Oxaliplatin
por: Kadina, Yulia A., et al.
Publicado: (2021)

Thermoreversible Poly(ethylene glycol)-g-Chitosan Hydrogel as a Therapeutic T Lymphocyte Depot for Localized Glioblastoma Immunotherapy
por: Tsao, Ching-Ting, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_lv819gctpdqer22febvbdsjejb