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Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins
BACKGROUND: Pin site infection is the most common and significant complication of external fixation. In this work, the efficacy of pins coated with titanium dioxide (TiO(2)) for inhibition of infection was compared with that of stainless steel control pins in an in vivo study. METHODS: Pins contamin...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575175/ https://www.ncbi.nlm.nih.gov/pubmed/23429667 http://dx.doi.org/10.2147/IJN.S39201 |
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author | Koseki, Hironobu Asahara, Tomohiko Shida, Takayuki Yoda, Itaru Horiuchi, Hidehiko Baba, Koumei Osaki, Makoto |
author_facet | Koseki, Hironobu Asahara, Tomohiko Shida, Takayuki Yoda, Itaru Horiuchi, Hidehiko Baba, Koumei Osaki, Makoto |
author_sort | Koseki, Hironobu |
collection | PubMed |
description | BACKGROUND: Pin site infection is the most common and significant complication of external fixation. In this work, the efficacy of pins coated with titanium dioxide (TiO(2)) for inhibition of infection was compared with that of stainless steel control pins in an in vivo study. METHODS: Pins contaminated with an identifiable Staphylococcus aureus strain were inserted into femoral bone in a rat model and exposed to ultraviolet A light for 30 minutes. On day 14, the animals were sacrificed and the bone and soft tissue around the pin were retrieved. The clinical findings and histological findings were evaluated in 60 samples. RESULTS: Clinical signs of infection were present in 76.7% of untreated pins, but in only 36.7% of TiO(2)-coated pins. The histological bone infection score and planimetric rate of occupation for bacterial colonies and neutrophils in the TiO(2)-coated pin group were lower than those in the control group. The bone-implant contact ratio of the TiO(2)-coated pin group was significantly higher (71.4%) than in the control pin group (58.2%). The TiO(2) was successful in decreasing infection both clinically and histomorphometrically. CONCLUSION: The photocatalytic bactericidal effect of TiO(2) is thought to be useful for inhibiting pin site infection after external fixation. |
format | Online Article Text |
id | pubmed-3575175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-35751752013-02-21 Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins Koseki, Hironobu Asahara, Tomohiko Shida, Takayuki Yoda, Itaru Horiuchi, Hidehiko Baba, Koumei Osaki, Makoto Int J Nanomedicine Original Research BACKGROUND: Pin site infection is the most common and significant complication of external fixation. In this work, the efficacy of pins coated with titanium dioxide (TiO(2)) for inhibition of infection was compared with that of stainless steel control pins in an in vivo study. METHODS: Pins contaminated with an identifiable Staphylococcus aureus strain were inserted into femoral bone in a rat model and exposed to ultraviolet A light for 30 minutes. On day 14, the animals were sacrificed and the bone and soft tissue around the pin were retrieved. The clinical findings and histological findings were evaluated in 60 samples. RESULTS: Clinical signs of infection were present in 76.7% of untreated pins, but in only 36.7% of TiO(2)-coated pins. The histological bone infection score and planimetric rate of occupation for bacterial colonies and neutrophils in the TiO(2)-coated pin group were lower than those in the control group. The bone-implant contact ratio of the TiO(2)-coated pin group was significantly higher (71.4%) than in the control pin group (58.2%). The TiO(2) was successful in decreasing infection both clinically and histomorphometrically. CONCLUSION: The photocatalytic bactericidal effect of TiO(2) is thought to be useful for inhibiting pin site infection after external fixation. Dove Medical Press 2013 2013-02-05 /pmc/articles/PMC3575175/ /pubmed/23429667 http://dx.doi.org/10.2147/IJN.S39201 Text en © 2013 Koseki et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Koseki, Hironobu Asahara, Tomohiko Shida, Takayuki Yoda, Itaru Horiuchi, Hidehiko Baba, Koumei Osaki, Makoto Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins |
title | Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins |
title_full | Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins |
title_fullStr | Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins |
title_full_unstemmed | Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins |
title_short | Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins |
title_sort | clinical and histomorphometrical study on titanium dioxide-coated external fixation pins |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575175/ https://www.ncbi.nlm.nih.gov/pubmed/23429667 http://dx.doi.org/10.2147/IJN.S39201 |
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