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EphB2 signaling regulates lesion-induced axon sprouting but not critical period length in the postnatal auditory brainstem

BACKGROUND: Studies of developmental plasticity may provide insight into plasticity during adulthood, when neural circuitry is less responsive to losses or changes in input. In the mammalian auditory brainstem, globular bushy cell axons of the ventral cochlear nucleus (VCN) innervate the contralater...

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Autores principales: Nakamura, Paul A, Cramer, Karina S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575227/
https://www.ncbi.nlm.nih.gov/pubmed/23379484
http://dx.doi.org/10.1186/1749-8104-8-2
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author Nakamura, Paul A
Cramer, Karina S
author_facet Nakamura, Paul A
Cramer, Karina S
author_sort Nakamura, Paul A
collection PubMed
description BACKGROUND: Studies of developmental plasticity may provide insight into plasticity during adulthood, when neural circuitry is less responsive to losses or changes in input. In the mammalian auditory brainstem, globular bushy cell axons of the ventral cochlear nucleus (VCN) innervate the contralateral medial nucleus of the trapezoid body (MNTB) principal neurons. VCN axonal terminations in MNTB, known as calyces of Held, are very large and specialized for high-fidelity transmission of auditory information. Following unilateral deafferentation during postnatal development, VCN axons from the intact side form connections with novel targets, including the ipsilateral MNTB. EphB signaling has been shown to play a role in this process during the first postnatal week, but mechanisms involved in this reorganization during later developmental periods remain unknown. RESULTS: We found that EphB2 signaling reduces the number of induced ipsilateral projections to the MNTB after unilateral VCN removal at postnatal day seven (P7), but not after removal of the VCN on one side at P10, after the closure of the critical period for lesion-induced innervation of the ipsilateral MNTB. CONCLUSIONS: Results from this study indicate that molecular mechanisms involved in the development of circuitry may also play a part in rewiring after deafferentation during development, but do not appear to regulate the length of critical periods for plasticity.
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spelling pubmed-35752272013-02-19 EphB2 signaling regulates lesion-induced axon sprouting but not critical period length in the postnatal auditory brainstem Nakamura, Paul A Cramer, Karina S Neural Dev Research Article BACKGROUND: Studies of developmental plasticity may provide insight into plasticity during adulthood, when neural circuitry is less responsive to losses or changes in input. In the mammalian auditory brainstem, globular bushy cell axons of the ventral cochlear nucleus (VCN) innervate the contralateral medial nucleus of the trapezoid body (MNTB) principal neurons. VCN axonal terminations in MNTB, known as calyces of Held, are very large and specialized for high-fidelity transmission of auditory information. Following unilateral deafferentation during postnatal development, VCN axons from the intact side form connections with novel targets, including the ipsilateral MNTB. EphB signaling has been shown to play a role in this process during the first postnatal week, but mechanisms involved in this reorganization during later developmental periods remain unknown. RESULTS: We found that EphB2 signaling reduces the number of induced ipsilateral projections to the MNTB after unilateral VCN removal at postnatal day seven (P7), but not after removal of the VCN on one side at P10, after the closure of the critical period for lesion-induced innervation of the ipsilateral MNTB. CONCLUSIONS: Results from this study indicate that molecular mechanisms involved in the development of circuitry may also play a part in rewiring after deafferentation during development, but do not appear to regulate the length of critical periods for plasticity. BioMed Central 2013-02-05 /pmc/articles/PMC3575227/ /pubmed/23379484 http://dx.doi.org/10.1186/1749-8104-8-2 Text en Copyright ©2013 Nakamura and Cramer; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nakamura, Paul A
Cramer, Karina S
EphB2 signaling regulates lesion-induced axon sprouting but not critical period length in the postnatal auditory brainstem
title EphB2 signaling regulates lesion-induced axon sprouting but not critical period length in the postnatal auditory brainstem
title_full EphB2 signaling regulates lesion-induced axon sprouting but not critical period length in the postnatal auditory brainstem
title_fullStr EphB2 signaling regulates lesion-induced axon sprouting but not critical period length in the postnatal auditory brainstem
title_full_unstemmed EphB2 signaling regulates lesion-induced axon sprouting but not critical period length in the postnatal auditory brainstem
title_short EphB2 signaling regulates lesion-induced axon sprouting but not critical period length in the postnatal auditory brainstem
title_sort ephb2 signaling regulates lesion-induced axon sprouting but not critical period length in the postnatal auditory brainstem
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575227/
https://www.ncbi.nlm.nih.gov/pubmed/23379484
http://dx.doi.org/10.1186/1749-8104-8-2
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