Cargando…

Can we clinically diagnose dementia with Lewy bodies yet?

Dementia with Lewy Bodies (DLB) was initially identified and confirmed primarily by pathology, but is soon to be incorporated into the Diagnostic and Statistical Manual criteria as a clinical disease entity. Despite these advances over more than 20 years, current data suggest that the sensitivity of...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Yue, Halliday, Glenda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575256/
https://www.ncbi.nlm.nih.gov/pubmed/23398715
http://dx.doi.org/10.1186/2047-9158-2-4
_version_ 1782259683546890240
author Huang, Yue
Halliday, Glenda
author_facet Huang, Yue
Halliday, Glenda
author_sort Huang, Yue
collection PubMed
description Dementia with Lewy Bodies (DLB) was initially identified and confirmed primarily by pathology, but is soon to be incorporated into the Diagnostic and Statistical Manual criteria as a clinical disease entity. Despite these advances over more than 20 years, current data suggest that the sensitivity of accurate clinical diagnosis of DLB is still very low, although there is mounting evidence that supportive features may increase diagnostic accuracy. Although DLB remains easy to identify pathologically with different cellular pathologies differentiating it from other dementia syndromes, pathological identification using only Lewy body pathology has been shown to be inaccurate due to overlap with patients without dementia symptoms. A number of studies now suggest that a combination of cellular pathologies, which include α-synuclein and β-amyloid deposition as well as dopamine denervation, assist with differentiating this dementia syndrome from others. The clinical and pathological overlap with the tauopathy of Alzheimer’s disease still remains to be clarified. To determine more robust and independent clinicopathological correlates from Alzheimer’s disease, longitudinal prospective studies, using specific clinical batteries on dementia patients reaching the proposed criteria for DLB, with post-mortem assessment of the multiple pathologies associated with dementia, are required. Identifying genetic causes for DLB is another approach to investigate the pathogenesis of DLB. However this approach has been hindered to date by difficulties with identifying DLB clinically. The use of novel techniques is likely to advance knowledge on the pathogenesis of DLB and assist with redefining clinical and pathologic diagnostic criteria. To achieve the goal of more accurate clinical diagnosis of DLB, breakthroughs are necessary on the pathogenesis of DLB.
format Online
Article
Text
id pubmed-3575256
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-35752562013-02-19 Can we clinically diagnose dementia with Lewy bodies yet? Huang, Yue Halliday, Glenda Transl Neurodegener Review Dementia with Lewy Bodies (DLB) was initially identified and confirmed primarily by pathology, but is soon to be incorporated into the Diagnostic and Statistical Manual criteria as a clinical disease entity. Despite these advances over more than 20 years, current data suggest that the sensitivity of accurate clinical diagnosis of DLB is still very low, although there is mounting evidence that supportive features may increase diagnostic accuracy. Although DLB remains easy to identify pathologically with different cellular pathologies differentiating it from other dementia syndromes, pathological identification using only Lewy body pathology has been shown to be inaccurate due to overlap with patients without dementia symptoms. A number of studies now suggest that a combination of cellular pathologies, which include α-synuclein and β-amyloid deposition as well as dopamine denervation, assist with differentiating this dementia syndrome from others. The clinical and pathological overlap with the tauopathy of Alzheimer’s disease still remains to be clarified. To determine more robust and independent clinicopathological correlates from Alzheimer’s disease, longitudinal prospective studies, using specific clinical batteries on dementia patients reaching the proposed criteria for DLB, with post-mortem assessment of the multiple pathologies associated with dementia, are required. Identifying genetic causes for DLB is another approach to investigate the pathogenesis of DLB. However this approach has been hindered to date by difficulties with identifying DLB clinically. The use of novel techniques is likely to advance knowledge on the pathogenesis of DLB and assist with redefining clinical and pathologic diagnostic criteria. To achieve the goal of more accurate clinical diagnosis of DLB, breakthroughs are necessary on the pathogenesis of DLB. BioMed Central 2013-02-11 /pmc/articles/PMC3575256/ /pubmed/23398715 http://dx.doi.org/10.1186/2047-9158-2-4 Text en Copyright ©2013 Huang and Halliday.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Huang, Yue
Halliday, Glenda
Can we clinically diagnose dementia with Lewy bodies yet?
title Can we clinically diagnose dementia with Lewy bodies yet?
title_full Can we clinically diagnose dementia with Lewy bodies yet?
title_fullStr Can we clinically diagnose dementia with Lewy bodies yet?
title_full_unstemmed Can we clinically diagnose dementia with Lewy bodies yet?
title_short Can we clinically diagnose dementia with Lewy bodies yet?
title_sort can we clinically diagnose dementia with lewy bodies yet?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575256/
https://www.ncbi.nlm.nih.gov/pubmed/23398715
http://dx.doi.org/10.1186/2047-9158-2-4
work_keys_str_mv AT huangyue canweclinicallydiagnosedementiawithlewybodiesyet
AT hallidayglenda canweclinicallydiagnosedementiawithlewybodiesyet