L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

BACKGROUND: In the central nervous system, astrocytic L-glutamate (L-Glu) transporters maintain extracellular L-Glu below neurotoxic levels, but their function is impaired with neuroinflammation. Microglia become activated with inflammation; however, the correlation between activated microglia and t...

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Detalles Bibliográficos
Autores principales: Takaki, Junpei, Fujimori, Koki, Miura, Marie, Suzuki, Takeshi, Sekino, Yuko, Sato, Kaoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575281/
https://www.ncbi.nlm.nih.gov/pubmed/23259598
http://dx.doi.org/10.1186/1742-2094-9-275

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