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Steroid hormone receptor expression in ovarian cancer: progesterone receptor B as prognostic marker for patient survival

BACKGROUND: There is partially conflicting evidence on the influence of the steroid hormones estrogen (E) and progesterone (P) on the development of ovarian cancer (OC). The aim of this study was to assess the expression of the receptor isoforms ER-α/-β and PR-A/-B in OC tissue and to analyze its im...

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Autores principales: Lenhard, Miriam, Tereza, Lennerová, Heublein, Sabine, Ditsch, Nina, Himsl, Isabelle, Mayr, Doris, Friese, Klaus, Jeschke, Udo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575289/
https://www.ncbi.nlm.nih.gov/pubmed/23176303
http://dx.doi.org/10.1186/1471-2407-12-553
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author Lenhard, Miriam
Tereza, Lennerová
Heublein, Sabine
Ditsch, Nina
Himsl, Isabelle
Mayr, Doris
Friese, Klaus
Jeschke, Udo
author_facet Lenhard, Miriam
Tereza, Lennerová
Heublein, Sabine
Ditsch, Nina
Himsl, Isabelle
Mayr, Doris
Friese, Klaus
Jeschke, Udo
author_sort Lenhard, Miriam
collection PubMed
description BACKGROUND: There is partially conflicting evidence on the influence of the steroid hormones estrogen (E) and progesterone (P) on the development of ovarian cancer (OC). The aim of this study was to assess the expression of the receptor isoforms ER-α/-β and PR-A/-B in OC tissue and to analyze its impact on clinical and pathological features and patient outcome. METHODS: 155 OC patients were included who had been diagnosed and treated between 1990 and 2002. Patient characteristics, histology and follow-up data were available. ER-α/-β and PR-A/-B expression were determined by immunohistochemistry. RESULTS: OC tissue was positive for ER-α/-β in 31.4% and 60.1% and PR-A/-B in 36.2% and 33.8%, respectively. We identified significant differences in ER-β expression related to the histological subtype (p=0.041), stage (p=0.002) and grade (p=0.011) as well as PR-A and tumor stage (p=0.03). Interestingly, median receptor expression for ER-α and PR-A/-B was significantly higher in G1 vs. G2 OC. Kaplan Meier analysis revealed a good prognosis for ER-α positive (p=0.039) and PR-B positive (p<0.001) OC. In contrast, ER-β negative OC had a favorable outcome (p=0.049). Besides tumor grade and stage, Cox-regression analysis showed PR-B to be an independent prognostic marker for patient survival (p=0.009, 95% CI 0.251-0.823, HR 0.455). CONCLUSION: ER-α/-β and PR-A/-B are frequently expressed in OC with a certain variability relating to histological subtype, grade and stage. Univariate analysis indicated a favorable outcome for ER-α positive and PR-B positive OC, while multivariate analysis showed PR-B to be the only independent prognostic marker for patient survival. In conclusion, ER and PR receptors may be useful targets for a more individualized OC therapy.
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spelling pubmed-35752892013-02-19 Steroid hormone receptor expression in ovarian cancer: progesterone receptor B as prognostic marker for patient survival Lenhard, Miriam Tereza, Lennerová Heublein, Sabine Ditsch, Nina Himsl, Isabelle Mayr, Doris Friese, Klaus Jeschke, Udo BMC Cancer Research Article BACKGROUND: There is partially conflicting evidence on the influence of the steroid hormones estrogen (E) and progesterone (P) on the development of ovarian cancer (OC). The aim of this study was to assess the expression of the receptor isoforms ER-α/-β and PR-A/-B in OC tissue and to analyze its impact on clinical and pathological features and patient outcome. METHODS: 155 OC patients were included who had been diagnosed and treated between 1990 and 2002. Patient characteristics, histology and follow-up data were available. ER-α/-β and PR-A/-B expression were determined by immunohistochemistry. RESULTS: OC tissue was positive for ER-α/-β in 31.4% and 60.1% and PR-A/-B in 36.2% and 33.8%, respectively. We identified significant differences in ER-β expression related to the histological subtype (p=0.041), stage (p=0.002) and grade (p=0.011) as well as PR-A and tumor stage (p=0.03). Interestingly, median receptor expression for ER-α and PR-A/-B was significantly higher in G1 vs. G2 OC. Kaplan Meier analysis revealed a good prognosis for ER-α positive (p=0.039) and PR-B positive (p<0.001) OC. In contrast, ER-β negative OC had a favorable outcome (p=0.049). Besides tumor grade and stage, Cox-regression analysis showed PR-B to be an independent prognostic marker for patient survival (p=0.009, 95% CI 0.251-0.823, HR 0.455). CONCLUSION: ER-α/-β and PR-A/-B are frequently expressed in OC with a certain variability relating to histological subtype, grade and stage. Univariate analysis indicated a favorable outcome for ER-α positive and PR-B positive OC, while multivariate analysis showed PR-B to be the only independent prognostic marker for patient survival. In conclusion, ER and PR receptors may be useful targets for a more individualized OC therapy. BioMed Central 2012-11-24 /pmc/articles/PMC3575289/ /pubmed/23176303 http://dx.doi.org/10.1186/1471-2407-12-553 Text en Copyright ©2012 Lenhard et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lenhard, Miriam
Tereza, Lennerová
Heublein, Sabine
Ditsch, Nina
Himsl, Isabelle
Mayr, Doris
Friese, Klaus
Jeschke, Udo
Steroid hormone receptor expression in ovarian cancer: progesterone receptor B as prognostic marker for patient survival
title Steroid hormone receptor expression in ovarian cancer: progesterone receptor B as prognostic marker for patient survival
title_full Steroid hormone receptor expression in ovarian cancer: progesterone receptor B as prognostic marker for patient survival
title_fullStr Steroid hormone receptor expression in ovarian cancer: progesterone receptor B as prognostic marker for patient survival
title_full_unstemmed Steroid hormone receptor expression in ovarian cancer: progesterone receptor B as prognostic marker for patient survival
title_short Steroid hormone receptor expression in ovarian cancer: progesterone receptor B as prognostic marker for patient survival
title_sort steroid hormone receptor expression in ovarian cancer: progesterone receptor b as prognostic marker for patient survival
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575289/
https://www.ncbi.nlm.nih.gov/pubmed/23176303
http://dx.doi.org/10.1186/1471-2407-12-553
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