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Genetic test feedback with weight control advice: study protocol for a randomized controlled trial

BACKGROUND: Genetic testing for risk of weight gain is already available over the internet despite uncertain benefits and concerns about adverse emotional or behavioral effects. Few studies have assessed the effect of adding genetic test feedback to weight control advice, even though one of the prop...

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Autores principales: Meisel, Susanne F, Beeken, Rebecca J, van Jaarsveld, Cornelia HM, Wardle, Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575361/
https://www.ncbi.nlm.nih.gov/pubmed/23216922
http://dx.doi.org/10.1186/1745-6215-13-235
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author Meisel, Susanne F
Beeken, Rebecca J
van Jaarsveld, Cornelia HM
Wardle, Jane
author_facet Meisel, Susanne F
Beeken, Rebecca J
van Jaarsveld, Cornelia HM
Wardle, Jane
author_sort Meisel, Susanne F
collection PubMed
description BACKGROUND: Genetic testing for risk of weight gain is already available over the internet despite uncertain benefits and concerns about adverse emotional or behavioral effects. Few studies have assessed the effect of adding genetic test feedback to weight control advice, even though one of the proposed applications of genetic testing is to stimulate preventive action. This study will investigate the motivational effect of adding genetic test feedback to simple weight control advice in a situation where weight gain is relatively common. METHODS/DESIGN: First-year university students (n = 800) will be randomized to receive either 1) their personal genetic test result for a gene (FTO) related to weight gain susceptibility in addition to a leaflet with simple weight control advice (‘Feedback + Advice’ group, FA), or 2) only the leaflet containing simple weight control advice (‘Advice Only’ group, AO). Motivation to avoid weight gain and active use of weight control strategies will be assessed one month after receipt of the leaflet with or without genetic test feedback. Weight and body fat will be measured at baseline and eight months follow-up. We will also assess short-term psychological reactions to the genetic test result. In addition, we will explore interactions between feedback condition and gene test status. DISCUSSION: We hope to provide a first indication of the clinical utility of weight-related genetic test feedback in the prevention context. TRIAL REGISTRATION: Current controlled trials ISRCTN91178663
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spelling pubmed-35753612013-02-19 Genetic test feedback with weight control advice: study protocol for a randomized controlled trial Meisel, Susanne F Beeken, Rebecca J van Jaarsveld, Cornelia HM Wardle, Jane Trials Study Protocol BACKGROUND: Genetic testing for risk of weight gain is already available over the internet despite uncertain benefits and concerns about adverse emotional or behavioral effects. Few studies have assessed the effect of adding genetic test feedback to weight control advice, even though one of the proposed applications of genetic testing is to stimulate preventive action. This study will investigate the motivational effect of adding genetic test feedback to simple weight control advice in a situation where weight gain is relatively common. METHODS/DESIGN: First-year university students (n = 800) will be randomized to receive either 1) their personal genetic test result for a gene (FTO) related to weight gain susceptibility in addition to a leaflet with simple weight control advice (‘Feedback + Advice’ group, FA), or 2) only the leaflet containing simple weight control advice (‘Advice Only’ group, AO). Motivation to avoid weight gain and active use of weight control strategies will be assessed one month after receipt of the leaflet with or without genetic test feedback. Weight and body fat will be measured at baseline and eight months follow-up. We will also assess short-term psychological reactions to the genetic test result. In addition, we will explore interactions between feedback condition and gene test status. DISCUSSION: We hope to provide a first indication of the clinical utility of weight-related genetic test feedback in the prevention context. TRIAL REGISTRATION: Current controlled trials ISRCTN91178663 BioMed Central 2012-12-06 /pmc/articles/PMC3575361/ /pubmed/23216922 http://dx.doi.org/10.1186/1745-6215-13-235 Text en Copyright ©2012 Meisel et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Study Protocol
Meisel, Susanne F
Beeken, Rebecca J
van Jaarsveld, Cornelia HM
Wardle, Jane
Genetic test feedback with weight control advice: study protocol for a randomized controlled trial
title Genetic test feedback with weight control advice: study protocol for a randomized controlled trial
title_full Genetic test feedback with weight control advice: study protocol for a randomized controlled trial
title_fullStr Genetic test feedback with weight control advice: study protocol for a randomized controlled trial
title_full_unstemmed Genetic test feedback with weight control advice: study protocol for a randomized controlled trial
title_short Genetic test feedback with weight control advice: study protocol for a randomized controlled trial
title_sort genetic test feedback with weight control advice: study protocol for a randomized controlled trial
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575361/
https://www.ncbi.nlm.nih.gov/pubmed/23216922
http://dx.doi.org/10.1186/1745-6215-13-235
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