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HLA-B35 and dsRNA Induce Endothelin-1 via Activation of ATF4 in Human Microvascular Endothelial Cells

Endothelin 1 (ET-1) is a key regulator of vascular homeostasis. We have recently reported that the presence of Human antigen class I, HLA-B35, contributes to human dermal microvascular endothelial cell (HDMEC) dysfunction by upregulating ET-1 and proinflammatory genes. Likewise, a Toll-like receptor...

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Detalles Bibliográficos
Autores principales:	Lenna, Stefania, Chrobak, Izabela, Farina, G. Alessandra, Rodriguez-Pascual, Fernando, Lamas, Santiago, Lafyatis, Robert, Scorza, Raffaella, Trojanowska, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575387/ https://www.ncbi.nlm.nih.gov/pubmed/23441162 http://dx.doi.org/10.1371/journal.pone.0056123

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