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Enhanced Effectivity of an ALK5-Inhibitor after Cell-Specific Delivery to Hepatic Stellate Cells in Mice with Liver Injury

Transforming growth factor-β (TGF-β) is a major pro-fibrotic cytokine, causing the overproduction of extracellular matrix molecules in many fibrotic diseases. Inhibition of its type-I receptor (ALK5) has been shown to effectively inhibit fibrosis in animal models. However, apart from its pro-fibroti...

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Detalles Bibliográficos
Autores principales:	van Beuge, Marike Marjolijn, Prakash, Jai, Lacombe, Marie, Post, Eduard, Reker-Smit, Catharina, Beljaars, Leonie, Poelstra, Klaas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575413/ https://www.ncbi.nlm.nih.gov/pubmed/23441194 http://dx.doi.org/10.1371/journal.pone.0056442

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