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Promoter reuse in prokaryotes
Anecdotal evidence shows promoters being reused separate from their downstream gene, thus providing a mechanism for the efficient and rapid rewiring of a gene’s transcriptional regulation. We have identified over 4000 groups of highly similar promoters using a conservative sequence similarity search...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575422/ https://www.ncbi.nlm.nih.gov/pubmed/23481313 http://dx.doi.org/10.4161/mge.23195 |
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author | Nijveen, Harm Matus-Garcia, Mariana van Passel, Mark Willem John |
author_facet | Nijveen, Harm Matus-Garcia, Mariana van Passel, Mark Willem John |
author_sort | Nijveen, Harm |
collection | PubMed |
description | Anecdotal evidence shows promoters being reused separate from their downstream gene, thus providing a mechanism for the efficient and rapid rewiring of a gene’s transcriptional regulation. We have identified over 4000 groups of highly similar promoters using a conservative sequence similarity search in all fully sequenced prokaryotic genomes. About 6% of those groups are shared between bacteria from different taxonomic depth, including different genera, families, orders, classes and even phyla. Database searches against known mobile elements and RNA motifs have indicated that regulatory motifs such as riboswitches could be moved around on putative mobile promoters. |
format | Online Article Text |
id | pubmed-3575422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-35754222013-03-11 Promoter reuse in prokaryotes Nijveen, Harm Matus-Garcia, Mariana van Passel, Mark Willem John Mob Genet Elements Commentary Anecdotal evidence shows promoters being reused separate from their downstream gene, thus providing a mechanism for the efficient and rapid rewiring of a gene’s transcriptional regulation. We have identified over 4000 groups of highly similar promoters using a conservative sequence similarity search in all fully sequenced prokaryotic genomes. About 6% of those groups are shared between bacteria from different taxonomic depth, including different genera, families, orders, classes and even phyla. Database searches against known mobile elements and RNA motifs have indicated that regulatory motifs such as riboswitches could be moved around on putative mobile promoters. Landes Bioscience 2012-11-01 /pmc/articles/PMC3575422/ /pubmed/23481313 http://dx.doi.org/10.4161/mge.23195 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Commentary Nijveen, Harm Matus-Garcia, Mariana van Passel, Mark Willem John Promoter reuse in prokaryotes |
title | Promoter reuse in prokaryotes |
title_full | Promoter reuse in prokaryotes |
title_fullStr | Promoter reuse in prokaryotes |
title_full_unstemmed | Promoter reuse in prokaryotes |
title_short | Promoter reuse in prokaryotes |
title_sort | promoter reuse in prokaryotes |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575422/ https://www.ncbi.nlm.nih.gov/pubmed/23481313 http://dx.doi.org/10.4161/mge.23195 |
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