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Integrons: Vehicles and pathways for horizontal dissemination in bacteria

Integrons are genetic elements first described at the end of the 1980s. Although most integrons were initially described in human clinical isolates, they have now been identified in many non-clinical environments, such as water and soil. Integrons are present in ≈10% of the sequenced bacterial genom...

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Detalles Bibliográficos
Autores principales: Domingues, Sara, da Silva, Gabriela J., Nielsen, Kaare M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575428/
https://www.ncbi.nlm.nih.gov/pubmed/23550063
http://dx.doi.org/10.4161/mge.22967
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author Domingues, Sara
da Silva, Gabriela J.
Nielsen, Kaare M.
author_facet Domingues, Sara
da Silva, Gabriela J.
Nielsen, Kaare M.
author_sort Domingues, Sara
collection PubMed
description Integrons are genetic elements first described at the end of the 1980s. Although most integrons were initially described in human clinical isolates, they have now been identified in many non-clinical environments, such as water and soil. Integrons are present in ≈10% of the sequenced bacterial genomes and are frequently linked to mobile genetic elements (MGEs); particularly the class 1 integrons. Genetic linkage to a diverse set of MGEs facilitates horizontal transfer of class 1 integrons within and between bacterial populations and species. The mechanistic aspects limiting transfer of MGEs will therefore limit the transfer of class 1 integrons. However, horizontal movement due to genes provided in trans and homologous recombination can result in class 1 integron dynamics independent of MGEs. A key determinant for continued dissemination of class 1 integrons is the probability that transferred MGEs will be vertically inherited in the recipient bacterial population. Heritability depends both on genetic stability as well as the fitness costs conferred to the host. Here we review the factors known to govern the dissemination of class 1 integrons in bacteria.
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spelling pubmed-35754282013-02-27 Integrons: Vehicles and pathways for horizontal dissemination in bacteria Domingues, Sara da Silva, Gabriela J. Nielsen, Kaare M. Mob Genet Elements Review Integrons are genetic elements first described at the end of the 1980s. Although most integrons were initially described in human clinical isolates, they have now been identified in many non-clinical environments, such as water and soil. Integrons are present in ≈10% of the sequenced bacterial genomes and are frequently linked to mobile genetic elements (MGEs); particularly the class 1 integrons. Genetic linkage to a diverse set of MGEs facilitates horizontal transfer of class 1 integrons within and between bacterial populations and species. The mechanistic aspects limiting transfer of MGEs will therefore limit the transfer of class 1 integrons. However, horizontal movement due to genes provided in trans and homologous recombination can result in class 1 integron dynamics independent of MGEs. A key determinant for continued dissemination of class 1 integrons is the probability that transferred MGEs will be vertically inherited in the recipient bacterial population. Heritability depends both on genetic stability as well as the fitness costs conferred to the host. Here we review the factors known to govern the dissemination of class 1 integrons in bacteria. Landes Bioscience 2012-09-01 /pmc/articles/PMC3575428/ /pubmed/23550063 http://dx.doi.org/10.4161/mge.22967 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Domingues, Sara
da Silva, Gabriela J.
Nielsen, Kaare M.
Integrons: Vehicles and pathways for horizontal dissemination in bacteria
title Integrons: Vehicles and pathways for horizontal dissemination in bacteria
title_full Integrons: Vehicles and pathways for horizontal dissemination in bacteria
title_fullStr Integrons: Vehicles and pathways for horizontal dissemination in bacteria
title_full_unstemmed Integrons: Vehicles and pathways for horizontal dissemination in bacteria
title_short Integrons: Vehicles and pathways for horizontal dissemination in bacteria
title_sort integrons: vehicles and pathways for horizontal dissemination in bacteria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575428/
https://www.ncbi.nlm.nih.gov/pubmed/23550063
http://dx.doi.org/10.4161/mge.22967
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