Exosomes: Looking back three decades and into the future

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Exosomes are extracellular membrane vesicles whose biogenesis by exocytosis of multivesicular endosomes was discovered in 1983. Since their discovery 30 years ago, it has become clear that exosomes contribute to many aspects of physiology and disease, including intercellular communication. We discus...

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Detalles Bibliográficos
Autores principales: Harding, Clifford V., Heuser, John E., Stahl, Philip D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575527/
https://www.ncbi.nlm.nih.gov/pubmed/23420870
http://dx.doi.org/10.1083/jcb.201212113
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author Harding, Clifford V.
Heuser, John E.
Stahl, Philip D.
author_facet Harding, Clifford V.
Heuser, John E.
Stahl, Philip D.
author_sort Harding, Clifford V.
collection PubMed
description Exosomes are extracellular membrane vesicles whose biogenesis by exocytosis of multivesicular endosomes was discovered in 1983. Since their discovery 30 years ago, it has become clear that exosomes contribute to many aspects of physiology and disease, including intercellular communication. We discuss the initial experiments that led to the discovery of exosomes and highlight some of the exciting current directions in the field.
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spelling pubmed-35755272013-08-18 Exosomes: Looking back three decades and into the future Harding, Clifford V. Heuser, John E. Stahl, Philip D. J Cell Biol Reviews Exosomes are extracellular membrane vesicles whose biogenesis by exocytosis of multivesicular endosomes was discovered in 1983. Since their discovery 30 years ago, it has become clear that exosomes contribute to many aspects of physiology and disease, including intercellular communication. We discuss the initial experiments that led to the discovery of exosomes and highlight some of the exciting current directions in the field. The Rockefeller University Press 2013-02-18 /pmc/articles/PMC3575527/ /pubmed/23420870 http://dx.doi.org/10.1083/jcb.201212113 Text en © 2013 Harding et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Harding, Clifford V.
Heuser, John E.
Stahl, Philip D.
Exosomes: Looking back three decades and into the future
title Exosomes: Looking back three decades and into the future
title_full Exosomes: Looking back three decades and into the future
title_fullStr Exosomes: Looking back three decades and into the future
title_full_unstemmed Exosomes: Looking back three decades and into the future
title_short Exosomes: Looking back three decades and into the future
title_sort exosomes: looking back three decades and into the future
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575527/
https://www.ncbi.nlm.nih.gov/pubmed/23420870
http://dx.doi.org/10.1083/jcb.201212113
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