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Clathrin and AP2 are required for PtdIns(4,5)P(2)-mediated formation of LRP6 signalosomes

Canonical Wnt signaling is initiated by the binding of Wnt proteins to their receptors, low-density lipoprotein-related protein 5 and 6 (LRP5/6) and frizzled proteins, leading to phosphatidylinositol (4,5)bisphosphate (PtdIns(4,5)P(2)) production, signalosome formation, and LRP phosphorylation. Howe...

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Detalles Bibliográficos
Autores principales:	Kim, Ingyu, Pan, Weijun, Jones, Sara A., Zhang, Youxin, Zhuang, Xiaowei, Wu, Dianqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575536/ https://www.ncbi.nlm.nih.gov/pubmed/23400998 http://dx.doi.org/10.1083/jcb.201206096

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