Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

Constitutive receptor tyrosine kinase phosphorylation requires regulation of kinase and phosphatase activity to prevent aberrant signal transduction. A dynamic mechanism is described here in which the adaptor protein, growth factor receptor–bound protein 2 (Grb2), controls fibroblast growth factor r...

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Detalles Bibliográficos
Autores principales: Ahmed, Zamal, Lin, Chi-Chuan, Suen, Kin M., Melo, Fernando A., Levitt, James A, Suhling, Klaus, Ladbury, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575544/
https://www.ncbi.nlm.nih.gov/pubmed/23420874
http://dx.doi.org/10.1083/jcb.201204106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575544/
https://www.ncbi.nlm.nih.gov/pubmed/23420874
http://dx.doi.org/10.1083/jcb.201204106

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