An emerging role for microRNA in the regulation of endothelin-1

Endothelin-1 (ET-1) is a peptide signaling molecule serving diverse functions in many different tissues such as the vasculature and the kidney. The primary mechanism thought to control ET-1 bioavailability is the rate of transcription from the ET-1 gene (EDN1), but recent research suggests that EDN1...

Descripción completa

Detalles Bibliográficos
Autores principales: Jacobs, Mollie E., Wingo, Charles S., Cain, Brian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575574/
https://www.ncbi.nlm.nih.gov/pubmed/23424003
http://dx.doi.org/10.3389/fphys.2013.00022
_version_ 1782259752014708736
author Jacobs, Mollie E.
Wingo, Charles S.
Cain, Brian D.
author_facet Jacobs, Mollie E.
Wingo, Charles S.
Cain, Brian D.
author_sort Jacobs, Mollie E.
collection PubMed
description Endothelin-1 (ET-1) is a peptide signaling molecule serving diverse functions in many different tissues such as the vasculature and the kidney. The primary mechanism thought to control ET-1 bioavailability is the rate of transcription from the ET-1 gene (EDN1), but recent research suggests that EDN1 expression is attenuated by microRNA (miRNA)—mediated regulation. The action of specific miRNAs on EDN1 mRNA appears to vary greatly in a tissue specific manner. This review provides a summary of our current understanding of miRNA-EDN1 interaction.
format Online
Article
Text
id pubmed-3575574
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-35755742013-02-19 An emerging role for microRNA in the regulation of endothelin-1 Jacobs, Mollie E. Wingo, Charles S. Cain, Brian D. Front Physiol Physiology Endothelin-1 (ET-1) is a peptide signaling molecule serving diverse functions in many different tissues such as the vasculature and the kidney. The primary mechanism thought to control ET-1 bioavailability is the rate of transcription from the ET-1 gene (EDN1), but recent research suggests that EDN1 expression is attenuated by microRNA (miRNA)—mediated regulation. The action of specific miRNAs on EDN1 mRNA appears to vary greatly in a tissue specific manner. This review provides a summary of our current understanding of miRNA-EDN1 interaction. Frontiers Media S.A. 2013-02-19 /pmc/articles/PMC3575574/ /pubmed/23424003 http://dx.doi.org/10.3389/fphys.2013.00022 Text en Copyright © 2013 Jacobs, Wingo and Cain. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Physiology
Jacobs, Mollie E.
Wingo, Charles S.
Cain, Brian D.
An emerging role for microRNA in the regulation of endothelin-1
title An emerging role for microRNA in the regulation of endothelin-1
title_full An emerging role for microRNA in the regulation of endothelin-1
title_fullStr An emerging role for microRNA in the regulation of endothelin-1
title_full_unstemmed An emerging role for microRNA in the regulation of endothelin-1
title_short An emerging role for microRNA in the regulation of endothelin-1
title_sort emerging role for microrna in the regulation of endothelin-1
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575574/
https://www.ncbi.nlm.nih.gov/pubmed/23424003
http://dx.doi.org/10.3389/fphys.2013.00022
work_keys_str_mv AT jacobsmolliee anemergingroleformicrornaintheregulationofendothelin1
AT wingocharless anemergingroleformicrornaintheregulationofendothelin1
AT cainbriand anemergingroleformicrornaintheregulationofendothelin1
AT jacobsmolliee emergingroleformicrornaintheregulationofendothelin1
AT wingocharless emergingroleformicrornaintheregulationofendothelin1
AT cainbriand emergingroleformicrornaintheregulationofendothelin1

Ejemplares similares