Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2

Estrogen receptor-α (ERα) is crucial for the adaptive response of bone to loading but the role of endogenous estradiol (E2) for this response is unclear. To determine in vivo the ligand dependency and relative roles of different ERα domains for the osteogenic response to mechanical loading, gene-tar...

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Detalles Bibliográficos
Autores principales: Windahl, Sara H, Saxon, Leanne, Börjesson, Anna E, Lagerquist, Marie K, Frenkel, Baruch, Henning, Petra, Lerner, Ulf H, Galea, Gabriel L, Meakin, Lee B, Engdahl, Cecilia, Sjögren, Klara, Antal, Maria C, Krust, Andrée, Chambon, Pierre, Lanyon, Lance E, Price, Joanna S, Ohlsson, Claes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575695/
https://www.ncbi.nlm.nih.gov/pubmed/22972752
http://dx.doi.org/10.1002/jbmr.1754

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