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Structural and functional evidence that Rad4 competes with Rad2 for binding to the Tfb1 subunit of TFIIH in NER

XPC/Rad4 (human/yeast) recruits transcription faction IIH (TFIIH) to the nucleotide excision repair (NER) complex through interactions with its p62/Tfb1 and XPB/Ssl2 subunits. TFIIH then recruits XPG/Rad2 through interactions with similar subunits and the two repair factors appear to be mutually exc...

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Detalles Bibliográficos
Autores principales:	Lafrance-Vanasse, Julien, Arseneault, Geneviève, Cappadocia, Laurent, Legault, Pascale, Omichinski, James G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575800/ https://www.ncbi.nlm.nih.gov/pubmed/23295669 http://dx.doi.org/10.1093/nar/gks1321

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