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Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains

The RNA helicase Upf1 is a multifaceted eukaryotic enzyme involved in DNA replication, telomere metabolism and several mRNA degradation pathways. Upf1 plays a central role in nonsense-mediated mRNA decay (NMD), a surveillance process in which it links premature translation termination to mRNA degrad...

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Detalles Bibliográficos
Autores principales:	Fiorini, Francesca, Boudvillain, Marc, Le Hir, Hervé
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575847/ https://www.ncbi.nlm.nih.gov/pubmed/23275559 http://dx.doi.org/10.1093/nar/gks1320

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