Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage

The E3 ubiquitin ligase Rad18 mediates tolerance of replication fork-stalling bulky DNA lesions, but whether Rad18 mediates tolerance of bulky DNA lesions acquired outside S-phase is unclear. Using synchronized cultures of primary human cells, we defined cell cycle stage-specific contributions of Ra...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Durando, Michael, Smith-Roe, Stephanie L., Sproul, Chris, Greenwalt, Alicia M., Kaufmann, William, Oh, Sehyun, Hendrickson, Eric A., Vaziri, Cyrus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575850/
https://www.ncbi.nlm.nih.gov/pubmed/23295675
http://dx.doi.org/10.1093/nar/gks1325

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