Critical Role for an Acidic Amino Acid Region in Platelet Signaling by the HemITAM (Hemi-immunoreceptor Tyrosine-based Activation Motif) Containing Receptor CLEC-2 (C-type Lectin Receptor-2)

CLEC-2 is a member of new family of C-type lectin receptors characterized by a cytosolic YXXL downstream of three acidic amino acids in a sequence known as a hemITAM (hemi-immunoreceptor tyrosine-based activation motif). Dimerization of two phosphorylated CLEC-2 molecules leads to recruitment of the...

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Detalles Bibliográficos
Autores principales: Hughes, Craig E., Sinha, Uma, Pandey, Anjali, Eble, Johannes A., O'Callaghan, Christopher A., Watson, Steve P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576117/
https://www.ncbi.nlm.nih.gov/pubmed/23264619
http://dx.doi.org/10.1074/jbc.M112.411462

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