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Transforming Growth Factor-β Directly Induces p53-up-regulated Modulator of Apoptosis (PUMA) during the Rapid Induction of Apoptosis in Myc-driven B-cell Lymphomas

c-Myc transformed human Burkitt's lymphoma (BL) cells are highly sensitive to TGF-β-induced apoptosis. Previously we demonstrated that TGF-β-mediated cell death in BL cells is regulated via the mitochondrial intrinsic apoptosis pathway, which is dependent on the activation of BAX and/or BAK. TG...

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Detalles Bibliográficos
Autores principales:	Spender, Lindsay C., Carter, Matthew J., O'Brien, Darren I., Clark, Louise J., Yu, Jian, Michalak, Ewa M., Happo, Lina, Cragg, Mark S., Inman, Gareth J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576124/ https://www.ncbi.nlm.nih.gov/pubmed/23243310 http://dx.doi.org/10.1074/jbc.M112.410274

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