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Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature

Over 200 cases of undifferentiated embryonal sarcoma of the liver (UESL) have been reported since 1978 when this disease was first described. In the present study, we describe a case of UESL in a 7-year-old female, whose initial symptoms included swelling in the upper abdomen and a palpable enormous...

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Autores principales: GAO, JIE, FEI, LIMING, LI, SHENG, CUI, KAI, ZHANG, JIANBO, YU, FACHANG, ZHANG, BO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576188/
https://www.ncbi.nlm.nih.gov/pubmed/23426588
http://dx.doi.org/10.3892/ol.2012.1087
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author GAO, JIE
FEI, LIMING
LI, SHENG
CUI, KAI
ZHANG, JIANBO
YU, FACHANG
ZHANG, BO
author_facet GAO, JIE
FEI, LIMING
LI, SHENG
CUI, KAI
ZHANG, JIANBO
YU, FACHANG
ZHANG, BO
author_sort GAO, JIE
collection PubMed
description Over 200 cases of undifferentiated embryonal sarcoma of the liver (UESL) have been reported since 1978 when this disease was first described. In the present study, we describe a case of UESL in a 7-year-old female, whose initial symptoms included swelling in the upper abdomen and a palpable enormous irregular tumor. A magnetic resonance imaging (MRI) examination revealed a massive focal lesion in the right lobe of the liver. Hepatic malignant tumor with a high possibility of hepatoblastoma was diagnosed. The tumor was surgically removed and confirmed to be UESL by postoperative pathology and immunohistochemical staining analysis. The patient then received chemotherapy consisting of three cycles of epirubicin (20 mg, days 1–2) and cisplatin (15 mg, days 1–3). To date, the patient has survived for 22 months, and is currently in a good general condition without evidence of local metastasis or recurrence. Although UESL has a high malignancy and a poor prognosis, cases of long-term survival with improved diagnosis and therapy have recently been reported. Therefore, it has been proposed that UESL should not be considered as an hepatic tumor with a poor prognosis. Total resection with preoperative or postoperative radio-chemotherapy is currently considered to be the key approach to improving the survival rate.
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spelling pubmed-35761882013-02-20 Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature GAO, JIE FEI, LIMING LI, SHENG CUI, KAI ZHANG, JIANBO YU, FACHANG ZHANG, BO Oncol Lett Articles Over 200 cases of undifferentiated embryonal sarcoma of the liver (UESL) have been reported since 1978 when this disease was first described. In the present study, we describe a case of UESL in a 7-year-old female, whose initial symptoms included swelling in the upper abdomen and a palpable enormous irregular tumor. A magnetic resonance imaging (MRI) examination revealed a massive focal lesion in the right lobe of the liver. Hepatic malignant tumor with a high possibility of hepatoblastoma was diagnosed. The tumor was surgically removed and confirmed to be UESL by postoperative pathology and immunohistochemical staining analysis. The patient then received chemotherapy consisting of three cycles of epirubicin (20 mg, days 1–2) and cisplatin (15 mg, days 1–3). To date, the patient has survived for 22 months, and is currently in a good general condition without evidence of local metastasis or recurrence. Although UESL has a high malignancy and a poor prognosis, cases of long-term survival with improved diagnosis and therapy have recently been reported. Therefore, it has been proposed that UESL should not be considered as an hepatic tumor with a poor prognosis. Total resection with preoperative or postoperative radio-chemotherapy is currently considered to be the key approach to improving the survival rate. D.A. Spandidos 2013-03 2012-12-19 /pmc/articles/PMC3576188/ /pubmed/23426588 http://dx.doi.org/10.3892/ol.2012.1087 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
GAO, JIE
FEI, LIMING
LI, SHENG
CUI, KAI
ZHANG, JIANBO
YU, FACHANG
ZHANG, BO
Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature
title Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature
title_full Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature
title_fullStr Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature
title_full_unstemmed Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature
title_short Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature
title_sort undifferentiated embryonal sarcoma of the liver in a child: a case report and review of the literature
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576188/
https://www.ncbi.nlm.nih.gov/pubmed/23426588
http://dx.doi.org/10.3892/ol.2012.1087
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