Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study

The aim of this study was to investigate the role of the XRCC1 Arg399Gln polymorphism in the susceptibility of a Kashmiri population to colorectal cancer (CRC). We investigated the genotype distribution of the XRCC1 gene in 130 CRC cases in comparison with that of 150 healthy subjects. There was no...

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Detalles Bibliográficos
Autores principales: NISSAR, SANIYA, LONE, TUFAIL AHMAD, BANDAY, MUJEEB ZAFAR, RASOOL, ROOHI, CHOWDRI, NISSAR A., PARRAY, FAZL Q., ABDULLAH, SAFIYA, SAMEER, AGA SYED
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576209/
https://www.ncbi.nlm.nih.gov/pubmed/23426866
http://dx.doi.org/10.3892/ol.2013.1104
Descripción
Sumario:The aim of this study was to investigate the role of the XRCC1 Arg399Gln polymorphism in the susceptibility of a Kashmiri population to colorectal cancer (CRC). We investigated the genotype distribution of the XRCC1 gene in 130 CRC cases in comparison with that of 150 healthy subjects. There was no direct significant association between the XRCC1 genotypes and CRC; however, the Arg/Gln genotype was associated with an elevated risk of CRC (OR>1.47) and the Gln/Gln variant genotype was associated with an increased risk of CRC in various clinicopathological parameters. This study suggests that the XRCC1 polymorphism is associated with an increased risk of CRC.

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