Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study

The aim of this study was to investigate the role of the XRCC1 Arg399Gln polymorphism in the susceptibility of a Kashmiri population to colorectal cancer (CRC). We investigated the genotype distribution of the XRCC1 gene in 130 CRC cases in comparison with that of 150 healthy subjects. There was no...

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Autores principales: NISSAR, SANIYA, LONE, TUFAIL AHMAD, BANDAY, MUJEEB ZAFAR, RASOOL, ROOHI, CHOWDRI, NISSAR A., PARRAY, FAZL Q., ABDULLAH, SAFIYA, SAMEER, AGA SYED
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576209/
https://www.ncbi.nlm.nih.gov/pubmed/23426866
http://dx.doi.org/10.3892/ol.2013.1104
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author NISSAR, SANIYA
LONE, TUFAIL AHMAD
BANDAY, MUJEEB ZAFAR
RASOOL, ROOHI
CHOWDRI, NISSAR A.
PARRAY, FAZL Q.
ABDULLAH, SAFIYA
SAMEER, AGA SYED
author_facet NISSAR, SANIYA
LONE, TUFAIL AHMAD
BANDAY, MUJEEB ZAFAR
RASOOL, ROOHI
CHOWDRI, NISSAR A.
PARRAY, FAZL Q.
ABDULLAH, SAFIYA
SAMEER, AGA SYED
author_sort NISSAR, SANIYA
collection PubMed
description The aim of this study was to investigate the role of the XRCC1 Arg399Gln polymorphism in the susceptibility of a Kashmiri population to colorectal cancer (CRC). We investigated the genotype distribution of the XRCC1 gene in 130 CRC cases in comparison with that of 150 healthy subjects. There was no direct significant association between the XRCC1 genotypes and CRC; however, the Arg/Gln genotype was associated with an elevated risk of CRC (OR>1.47) and the Gln/Gln variant genotype was associated with an increased risk of CRC in various clinicopathological parameters. This study suggests that the XRCC1 polymorphism is associated with an increased risk of CRC.
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spelling pubmed-35762092013-02-20 Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study NISSAR, SANIYA LONE, TUFAIL AHMAD BANDAY, MUJEEB ZAFAR RASOOL, ROOHI CHOWDRI, NISSAR A. PARRAY, FAZL Q. ABDULLAH, SAFIYA SAMEER, AGA SYED Oncol Lett Articles The aim of this study was to investigate the role of the XRCC1 Arg399Gln polymorphism in the susceptibility of a Kashmiri population to colorectal cancer (CRC). We investigated the genotype distribution of the XRCC1 gene in 130 CRC cases in comparison with that of 150 healthy subjects. There was no direct significant association between the XRCC1 genotypes and CRC; however, the Arg/Gln genotype was associated with an elevated risk of CRC (OR>1.47) and the Gln/Gln variant genotype was associated with an increased risk of CRC in various clinicopathological parameters. This study suggests that the XRCC1 polymorphism is associated with an increased risk of CRC. D.A. Spandidos 2013-03 2013-01-03 /pmc/articles/PMC3576209/ /pubmed/23426866 http://dx.doi.org/10.3892/ol.2013.1104 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
NISSAR, SANIYA
LONE, TUFAIL AHMAD
BANDAY, MUJEEB ZAFAR
RASOOL, ROOHI
CHOWDRI, NISSAR A.
PARRAY, FAZL Q.
ABDULLAH, SAFIYA
SAMEER, AGA SYED
Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study
title Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study
title_full Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study
title_fullStr Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study
title_full_unstemmed Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study
title_short Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study
title_sort arg399gln polymorphism of xrcc1 gene and risk of colorectal cancer in kashmir: a case control study
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576209/
https://www.ncbi.nlm.nih.gov/pubmed/23426866
http://dx.doi.org/10.3892/ol.2013.1104
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