UtroUp is a novel six zinc finger artificial transcription factor that recognises 18 base pairs of the utrophin promoter and efficiently drives utrophin upregulation

BACKGROUND: Duchenne muscular dystrophy (DMD) is the most common X-linked muscle degenerative disease and it is due to the absence of the cytoskeletal protein dystrophin. Currently there is no effective treatment for DMD. Among the different strategies for achieving a functional recovery of the dyst...

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Detalles Bibliográficos
Autores principales: Onori, Annalisa, Pisani, Cinzia, Strimpakos, Georgios, Monaco, Lucia, Mattei, Elisabetta, Passananti, Claudio, Corbi, Nicoletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576267/
https://www.ncbi.nlm.nih.gov/pubmed/23363418
http://dx.doi.org/10.1186/1471-2199-14-3

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