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Basal Forebrain Activation Enhances Cortical Coding of Natural Scenes
The nucleus basalis (NB) of the basal forebrain is an essential component of the neuromodulatory system controlling the behavioral state of an animal, and it is thought to play key roles in regulating arousal and attention. However, the effect of NB activation on sensory processing remains poorly un...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576925/ https://www.ncbi.nlm.nih.gov/pubmed/19801988 http://dx.doi.org/10.1038/nn.2402 |
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author | Goard, Michael Dan, Yang |
author_facet | Goard, Michael Dan, Yang |
author_sort | Goard, Michael |
collection | PubMed |
description | The nucleus basalis (NB) of the basal forebrain is an essential component of the neuromodulatory system controlling the behavioral state of an animal, and it is thought to play key roles in regulating arousal and attention. However, the effect of NB activation on sensory processing remains poorly understood. Using polytrode recording in rat visual cortex, we show that NB stimulation causes prominent decorrelation between neurons and marked improvement in the reliability of neuronal responses to natural scenes. The decorrelation depends on local activation of cortical muscarinic acetylcholine receptors, while the increased reliability involves distributed neural circuits, as evidenced by NB-induced changes in thalamic responses. Further analysis showed that the decorrelation and increased reliability improve cortical representation of natural stimuli in a complementary manner. Thus, the basal forebrain neuromodulatory circuit, which is known to be activated during aroused and attentive states, acts through both local and distributed mechanisms to improve sensory coding. |
format | Online Article Text |
id | pubmed-3576925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
record_format | MEDLINE/PubMed |
spelling | pubmed-35769252013-02-20 Basal Forebrain Activation Enhances Cortical Coding of Natural Scenes Goard, Michael Dan, Yang Nat Neurosci Article The nucleus basalis (NB) of the basal forebrain is an essential component of the neuromodulatory system controlling the behavioral state of an animal, and it is thought to play key roles in regulating arousal and attention. However, the effect of NB activation on sensory processing remains poorly understood. Using polytrode recording in rat visual cortex, we show that NB stimulation causes prominent decorrelation between neurons and marked improvement in the reliability of neuronal responses to natural scenes. The decorrelation depends on local activation of cortical muscarinic acetylcholine receptors, while the increased reliability involves distributed neural circuits, as evidenced by NB-induced changes in thalamic responses. Further analysis showed that the decorrelation and increased reliability improve cortical representation of natural stimuli in a complementary manner. Thus, the basal forebrain neuromodulatory circuit, which is known to be activated during aroused and attentive states, acts through both local and distributed mechanisms to improve sensory coding. 2009-10-04 2009-11 /pmc/articles/PMC3576925/ /pubmed/19801988 http://dx.doi.org/10.1038/nn.2402 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Goard, Michael Dan, Yang Basal Forebrain Activation Enhances Cortical Coding of Natural Scenes |
title | Basal Forebrain Activation Enhances Cortical Coding of Natural Scenes |
title_full | Basal Forebrain Activation Enhances Cortical Coding of Natural Scenes |
title_fullStr | Basal Forebrain Activation Enhances Cortical Coding of Natural Scenes |
title_full_unstemmed | Basal Forebrain Activation Enhances Cortical Coding of Natural Scenes |
title_short | Basal Forebrain Activation Enhances Cortical Coding of Natural Scenes |
title_sort | basal forebrain activation enhances cortical coding of natural scenes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576925/ https://www.ncbi.nlm.nih.gov/pubmed/19801988 http://dx.doi.org/10.1038/nn.2402 |
work_keys_str_mv | AT goardmichael basalforebrainactivationenhancescorticalcodingofnaturalscenes AT danyang basalforebrainactivationenhancescorticalcodingofnaturalscenes |