Emergence of new lineage of Dengue virus 3 (genotype III) in Lucknow, India

BACKGROUND AND OBJECTIVES: Dengue has re-emerged as an important arboviral disease causing significant morbidity. It has become hyperendemic in the Indian subcontinent with all four known dengue serotypes circulating. MATERIALS AND METHODS: Multiple sequence alignments and phylogenetic trees of DENV...

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Detalles Bibliográficos
Autores principales: Tripathi, Sanjeev Kumar, Gupta, Prashant, Khare, Vineeta, Chatterjee, Animesh, Kumar, Rashmi, Khan, Mohammed Yahiya, Dhole, Tapan N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577557/
https://www.ncbi.nlm.nih.gov/pubmed/23466682
Descripción
Sumario:BACKGROUND AND OBJECTIVES: Dengue has re-emerged as an important arboviral disease causing significant morbidity. It has become hyperendemic in the Indian subcontinent with all four known dengue serotypes circulating. MATERIALS AND METHODS: Multiple sequence alignments and phylogenetic trees of DENV-3 were constructed to determine the extent of the isolated dengue virus genetic heterogeneity and phylogeny. RESULTS: Sequencing and phylogenetic analysis of the C-prM gene junction revealed an active circulation of a new lineage of DENV-3 (genotype III) in this region of India. CONCLUSION: Continuous epidemiological surveillance to monitor the incursion and spread of dengue virus genotypes in this region of India is needed.

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