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Cardiac dynamics: a simplified model for action potential propagation

This paper analyzes a new semiphysiological ionic model, used recently to study reexitations and reentry in cardiac tissue [I.R. Cantalapiedra et al, PRE 82 011907 (2010)]. The aim of the model is to reproduce action potencial morphologies and restitution curves obtained, either from experimental da...

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Detalles Bibliográficos
Autores principales: Peñaranda, Angelina, Cantalapiedra, Inma R, Bragard, Jean, Echebarria, Blas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577582/
https://www.ncbi.nlm.nih.gov/pubmed/23194429
http://dx.doi.org/10.1186/1742-4682-9-50
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author Peñaranda, Angelina
Cantalapiedra, Inma R
Bragard, Jean
Echebarria, Blas
author_facet Peñaranda, Angelina
Cantalapiedra, Inma R
Bragard, Jean
Echebarria, Blas
author_sort Peñaranda, Angelina
collection PubMed
description This paper analyzes a new semiphysiological ionic model, used recently to study reexitations and reentry in cardiac tissue [I.R. Cantalapiedra et al, PRE 82 011907 (2010)]. The aim of the model is to reproduce action potencial morphologies and restitution curves obtained, either from experimental data, or from more complex electrophysiological models. The model divides all ion currents into four groups according to their function, thus resulting into fast-slow and inward-outward currents. We show that this simplified model is flexible enough as to accurately capture the electrical properties of cardiac myocytes, having the advantage of being less computational demanding than detailed electrophysiological models. Under some conditions, it has been shown to be amenable to mathematical analysis. The model reproduces the action potential (AP) change with stimulation rate observed both experimentally and in realistic models of healthy human and guinea pig myocytes (TNNP and LRd models, respectively). When simulated in a cable it also gives the right dependence of the conduction velocity (CV) with stimulation rate. Besides reproducing correctly these restitution properties, it also gives a good fit for the morphology of the AP, including the notch typical of phase 1. Finally, we perform simulations in a realistic geometric model of the rabbit’s ventricles, finding a good qualitative agreement in AP propagation and the ECG. Thus, this simplified model represents an alternative to more complex models when studying instabilities in wave propagation.
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spelling pubmed-35775822013-02-26 Cardiac dynamics: a simplified model for action potential propagation Peñaranda, Angelina Cantalapiedra, Inma R Bragard, Jean Echebarria, Blas Theor Biol Med Model Research This paper analyzes a new semiphysiological ionic model, used recently to study reexitations and reentry in cardiac tissue [I.R. Cantalapiedra et al, PRE 82 011907 (2010)]. The aim of the model is to reproduce action potencial morphologies and restitution curves obtained, either from experimental data, or from more complex electrophysiological models. The model divides all ion currents into four groups according to their function, thus resulting into fast-slow and inward-outward currents. We show that this simplified model is flexible enough as to accurately capture the electrical properties of cardiac myocytes, having the advantage of being less computational demanding than detailed electrophysiological models. Under some conditions, it has been shown to be amenable to mathematical analysis. The model reproduces the action potential (AP) change with stimulation rate observed both experimentally and in realistic models of healthy human and guinea pig myocytes (TNNP and LRd models, respectively). When simulated in a cable it also gives the right dependence of the conduction velocity (CV) with stimulation rate. Besides reproducing correctly these restitution properties, it also gives a good fit for the morphology of the AP, including the notch typical of phase 1. Finally, we perform simulations in a realistic geometric model of the rabbit’s ventricles, finding a good qualitative agreement in AP propagation and the ECG. Thus, this simplified model represents an alternative to more complex models when studying instabilities in wave propagation. BioMed Central 2012-11-29 /pmc/articles/PMC3577582/ /pubmed/23194429 http://dx.doi.org/10.1186/1742-4682-9-50 Text en Copyright ©2012 Peñaranda et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Peñaranda, Angelina
Cantalapiedra, Inma R
Bragard, Jean
Echebarria, Blas
Cardiac dynamics: a simplified model for action potential propagation
title Cardiac dynamics: a simplified model for action potential propagation
title_full Cardiac dynamics: a simplified model for action potential propagation
title_fullStr Cardiac dynamics: a simplified model for action potential propagation
title_full_unstemmed Cardiac dynamics: a simplified model for action potential propagation
title_short Cardiac dynamics: a simplified model for action potential propagation
title_sort cardiac dynamics: a simplified model for action potential propagation
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577582/
https://www.ncbi.nlm.nih.gov/pubmed/23194429
http://dx.doi.org/10.1186/1742-4682-9-50
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