Age-Dependent Decrease and Alternative Splicing of Methionine Synthase mRNA in Human Cerebral Cortex and an Accelerated Decrease in Autism

The folate and vitamin B12-dependent enzyme methionine synthase (MS) is highly sensitive to cellular oxidative status, and lower MS activity increases production of the antioxidant glutathione, while simultaneously decreasing more than 200 methylation reactions, broadly affecting metabolic activity....

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Detalles Bibliográficos
Autores principales: Muratore, Christina R., Hodgson, Nathaniel W., Trivedi, Malav S., Abdolmaleky, Hamid M., Persico, Antonio M., Lintas, Carla, De La Monte, Suzanne, Deth, Richard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577685/
https://www.ncbi.nlm.nih.gov/pubmed/23437274
http://dx.doi.org/10.1371/journal.pone.0056927

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