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SNPs Identified as Modulators of ECG Traits in the General Population Do Not Markedly Affect ECG Traits during Acute Myocardial Infarction nor Ventricular Fibrillation Risk in This Condition

BACKGROUND: Ventricular fibrillation (VF) in the setting of acute ST elevation myocardial infarction (STEMI) is a leading cause of mortality. Although the risk of VF has a genetic component, the underlying genetic factors are largely unknown. Since heart rate and ECG intervals of conduction and repo...

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Autores principales: Pazoki, Raha, de Jong, Jonas S.S.G., Marsman, Roos F., Bruinsma, Nienke, Dekker, Lukas R. C., Wilde, Arthur A. M., Bezzina, Connie R., Tanck, Michael W. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577709/
https://www.ncbi.nlm.nih.gov/pubmed/23437344
http://dx.doi.org/10.1371/journal.pone.0057216
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author Pazoki, Raha
de Jong, Jonas S.S.G.
Marsman, Roos F.
Bruinsma, Nienke
Dekker, Lukas R. C.
Wilde, Arthur A. M.
Bezzina, Connie R.
Tanck, Michael W. T.
author_facet Pazoki, Raha
de Jong, Jonas S.S.G.
Marsman, Roos F.
Bruinsma, Nienke
Dekker, Lukas R. C.
Wilde, Arthur A. M.
Bezzina, Connie R.
Tanck, Michael W. T.
author_sort Pazoki, Raha
collection PubMed
description BACKGROUND: Ventricular fibrillation (VF) in the setting of acute ST elevation myocardial infarction (STEMI) is a leading cause of mortality. Although the risk of VF has a genetic component, the underlying genetic factors are largely unknown. Since heart rate and ECG intervals of conduction and repolarization during acute STEMI differ between patients who do and patients who do not develop VF, we investigated whether SNPs known to modulate these ECG indices in the general population also impact on the respective ECG indices during STEMI and on the risk of VF. METHODS AND RESULTS: The study population consisted of participants of the Arrhythmia Genetics in the NEtherlandS (AGNES) study, which enrols patients with a first STEMI that develop VF (cases) and patients that do not develop VF (controls). SNPs known to impact on RR interval, PR interval, QRS duration or QTc interval in the general population were tested for effects on the respective STEMI ECG indices (stage 1). Only those showing a (suggestive) significant association were tested for association with VF (stage 2). On average, VF cases had a shorter RR and a longer QTc interval compared to non-VF controls. Eight SNPs showed a trend for association with the respective STEMI ECG indices. Of these, three were also suggestively associated with VF. CONCLUSIONS: RR interval and ECG indices of conduction and repolarization during acute STEMI differ between patients who develop VF and patients who do not. Although the effects of the SNPs on ECG indices during an acute STEMI seem to be similar in magnitude and direction as those found in the general population, the effects, at least in isolation, are too small to explain the differences in ECGs between cases and controls and to determine risk of VF.
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spelling pubmed-35777092013-02-22 SNPs Identified as Modulators of ECG Traits in the General Population Do Not Markedly Affect ECG Traits during Acute Myocardial Infarction nor Ventricular Fibrillation Risk in This Condition Pazoki, Raha de Jong, Jonas S.S.G. Marsman, Roos F. Bruinsma, Nienke Dekker, Lukas R. C. Wilde, Arthur A. M. Bezzina, Connie R. Tanck, Michael W. T. PLoS One Research Article BACKGROUND: Ventricular fibrillation (VF) in the setting of acute ST elevation myocardial infarction (STEMI) is a leading cause of mortality. Although the risk of VF has a genetic component, the underlying genetic factors are largely unknown. Since heart rate and ECG intervals of conduction and repolarization during acute STEMI differ between patients who do and patients who do not develop VF, we investigated whether SNPs known to modulate these ECG indices in the general population also impact on the respective ECG indices during STEMI and on the risk of VF. METHODS AND RESULTS: The study population consisted of participants of the Arrhythmia Genetics in the NEtherlandS (AGNES) study, which enrols patients with a first STEMI that develop VF (cases) and patients that do not develop VF (controls). SNPs known to impact on RR interval, PR interval, QRS duration or QTc interval in the general population were tested for effects on the respective STEMI ECG indices (stage 1). Only those showing a (suggestive) significant association were tested for association with VF (stage 2). On average, VF cases had a shorter RR and a longer QTc interval compared to non-VF controls. Eight SNPs showed a trend for association with the respective STEMI ECG indices. Of these, three were also suggestively associated with VF. CONCLUSIONS: RR interval and ECG indices of conduction and repolarization during acute STEMI differ between patients who develop VF and patients who do not. Although the effects of the SNPs on ECG indices during an acute STEMI seem to be similar in magnitude and direction as those found in the general population, the effects, at least in isolation, are too small to explain the differences in ECGs between cases and controls and to determine risk of VF. Public Library of Science 2013-02-20 /pmc/articles/PMC3577709/ /pubmed/23437344 http://dx.doi.org/10.1371/journal.pone.0057216 Text en © 2013 Pazoki et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Pazoki, Raha
de Jong, Jonas S.S.G.
Marsman, Roos F.
Bruinsma, Nienke
Dekker, Lukas R. C.
Wilde, Arthur A. M.
Bezzina, Connie R.
Tanck, Michael W. T.
SNPs Identified as Modulators of ECG Traits in the General Population Do Not Markedly Affect ECG Traits during Acute Myocardial Infarction nor Ventricular Fibrillation Risk in This Condition
title SNPs Identified as Modulators of ECG Traits in the General Population Do Not Markedly Affect ECG Traits during Acute Myocardial Infarction nor Ventricular Fibrillation Risk in This Condition
title_full SNPs Identified as Modulators of ECG Traits in the General Population Do Not Markedly Affect ECG Traits during Acute Myocardial Infarction nor Ventricular Fibrillation Risk in This Condition
title_fullStr SNPs Identified as Modulators of ECG Traits in the General Population Do Not Markedly Affect ECG Traits during Acute Myocardial Infarction nor Ventricular Fibrillation Risk in This Condition
title_full_unstemmed SNPs Identified as Modulators of ECG Traits in the General Population Do Not Markedly Affect ECG Traits during Acute Myocardial Infarction nor Ventricular Fibrillation Risk in This Condition
title_short SNPs Identified as Modulators of ECG Traits in the General Population Do Not Markedly Affect ECG Traits during Acute Myocardial Infarction nor Ventricular Fibrillation Risk in This Condition
title_sort snps identified as modulators of ecg traits in the general population do not markedly affect ecg traits during acute myocardial infarction nor ventricular fibrillation risk in this condition
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577709/
https://www.ncbi.nlm.nih.gov/pubmed/23437344
http://dx.doi.org/10.1371/journal.pone.0057216
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