Dysregulation of Protease and Protease Inhibitors in a Mouse Model of Human Pelvic Organ Prolapse

Mice deficient for the fibulin-5 gene (Fbln5(−/−)) develop pelvic organ prolapse (POP) due to compromised elastic fibers and upregulation of matrix metalloprotease (MMP)-9. Here, we used casein zymography, inhibitor profiling, affinity pull-down, and mass spectrometry to discover additional protease...

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Detalles Bibliográficos
Autores principales: Budatha, Madhusudhan, Silva, Simone, Montoya, Teodoro Ignacio, Suzuki, Ayako, Shah-Simpson, Sheena, Wieslander, Cecilia Karin, Yanagisawa, Masashi, Word, Ruth Ann, Yanagisawa, Hiromi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577807/
https://www.ncbi.nlm.nih.gov/pubmed/23437119
http://dx.doi.org/10.1371/journal.pone.0056376

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