Biological Characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a Selective Sphingosine Kinase-2 Inhibitor and Anticancer Agent

In our effort to develop selective sphingosine kinase-2 (SphK2) inhibitors as pharmacological tools, a thiazolidine-2,4-dione analogue, 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145), was synthesized and biologically characterized. Biochemical assay results indi...

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Detalles Bibliográficos
Autores principales: Liu, Kai, Guo, Tai L., Hait, Nitai C., Allegood, Jeremy, Parikh, Hardik I., Xu, Wenfang, Kellogg, Glen E., Grant, Steven, Spiegel, Sarah, Zhang, Shijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577900/
https://www.ncbi.nlm.nih.gov/pubmed/23437140
http://dx.doi.org/10.1371/journal.pone.0056471

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