Late Onset CNS Immune Reconstitution Inflammatory Syndrome in an Immunocompetent Patient

Immune reconstitution inflammatory syndrome (IRIS) refers to the presence of paradoxical clinical deterioration attributable to immune system recovery during highly active antiretroviral therapy (HAART). We present an immunocompetent patient with multifocal leukoencephalopathy on HAART, with central...

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Detalles Bibliográficos
Autores principales: Hornik, Alejandro, Rodriguez-Porcel, Federico, Wallery, Shawn, Flaster, Murray, Lee, John M., Biller, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578199/
https://www.ncbi.nlm.nih.gov/pubmed/23439663
http://dx.doi.org/10.3389/fneur.2013.00012
Descripción
Sumario:Immune reconstitution inflammatory syndrome (IRIS) refers to the presence of paradoxical clinical deterioration attributable to immune system recovery during highly active antiretroviral therapy (HAART). We present an immunocompetent patient with multifocal leukoencephalopathy on HAART, with central nervous system (CNS) IRIS pathology of unknown infectious etiology. CNS IRIS pathology should be suspected in patients on longstanding HAART without immune reconstitution, presenting with unexplained leukoencephalopathy.

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