Cytotoxic effect and molecular docking of 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)-thiosemicarbazide—a novel topoisomerase II inhibitor

The preliminary cytotoxic effect of 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)-thiosemicarbazide hydrochloride (1)—a potent topoisomerase II inhibitor—was measured using a MTT assay. It was found that the compound decreased the number of viable cells in both estrogen receptor-positive MCF-7 a...

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Detalles Bibliográficos
Autores principales: Siwek, Agata, Stączek, Paweł, Wujec, Monika, Bielawski, Krzysztof, Bielawska, Anna, Paneth, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578725/
https://www.ncbi.nlm.nih.gov/pubmed/23187686
http://dx.doi.org/10.1007/s00894-012-1679-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578725/
https://www.ncbi.nlm.nih.gov/pubmed/23187686
http://dx.doi.org/10.1007/s00894-012-1679-6

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