Cargando…

Cytotoxic effect and molecular docking of 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)-thiosemicarbazide—a novel topoisomerase II inhibitor

The preliminary cytotoxic effect of 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)-thiosemicarbazide hydrochloride (1)—a potent topoisomerase II inhibitor—was measured using a MTT assay. It was found that the compound decreased the number of viable cells in both estrogen receptor-positive MCF-7 a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siwek, Agata, Stączek, Paweł, Wujec, Monika, Bielawski, Krzysztof, Bielawska, Anna, Paneth, Piotr
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2012
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578725/ https://www.ncbi.nlm.nih.gov/pubmed/23187686 http://dx.doi.org/10.1007/s00894-012-1679-6

Ejemplares similares

Thiosemicarbazide Derivatives Decrease the ATPase Activity of Staphylococcus aureus Topoisomerase IV, Inhibit Mycobacterial Growth, and Affect Replication in Mycobacterium smegmatis
por: Kowalczyk, Aleksandra, et al.
Publicado: (2021)

1,4-Disubstituted Thiosemicarbazide Derivatives are Potent Inhibitors of Toxoplasma gondii Proliferation
por: Dzitko, Katarzyna, et al.
Publicado: (2014)

Lipophilicity Studies on Thiosemicarbazide Derivatives
por: Paneth, Agata, et al.
Publicado: (2017)

Methyl 4-(piperidin-1-ylcarbonyl)benzoate
por: Ávila, R. M. D., et al.
Publicado: (2010)

1,4-Bis(piperidin-1-ylcarbonyl)benzene
por: Armbrust, Lee, et al.
Publicado: (2007)

Synergistic Effects of Thiosemicarbazides with Clinical Drugs against S. aureus
por: Chudzik-Rząd, Beata, et al.
Publicado: (2020)

Synthesis and Anthelmintic Activity of New Thiosemicarbazide Derivatives—A Preliminary Study
por: Dziduch, Katarzyna, et al.
Publicado: (2020)

Systematic Identification of Thiosemicarbazides for Inhibition of Toxoplasma gondii Growth In Vitro
por: Paneth, Agata, et al.
Publicado: (2019)

4-(2-Methylpiperidin-1-ylcarbonyl)pyridinium hexachloridoantimonate(V)
por: Wang, Bo
Publicado: (2009)

Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives—A Review
por: Janowska, Sara, et al.
Publicado: (2020)

Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates
por: Vigante, Brigita, et al.
Publicado: (2015)

DNA topoisomerases as molecular targets for anticancer drugs
por: Buzun, Kamila, et al.
Publicado: (2020)

Ethoxycarbonylmethyl ursolate
por: Yang, Wei, et al.
Publicado: (2008)

Discovery of Potent and Selective Halogen-Substituted Imidazole-Thiosemicarbazides for Inhibition of Toxoplasma gondii Growth In Vitro via Structure-Based Design
por: Paneth, Agata, et al.
Publicado: (2019)

Antifungal effect of 4-arylthiosemicarbazides against Candida species. Search for molecular basis of antifungal activity of thiosemicarbazide derivatives
por: Siwek, Agata, et al.
Publicado: (2012)

Design, Synthesis, Antibacterial Evaluations and In Silico Studies of Novel Thiosemicarbazides and 1,3,4-Thiadiazoles
por: Janowska, Sara, et al.
Publicado: (2022)

Synthesis and Anticancer Activity of 1,3,4-Thiadiazoles with 3-Methoxyphenyl Substituent
por: Janowska, Sara, et al.
Publicado: (2022)

Design, Synthesis, and Fungicidal Activity of Novel Thiosemicarbazide Derivatives Containing Piperidine Fragments
por: Zhang, Xuebo, et al.
Publicado: (2017)

Studies on the Anticonvulsant Activity and Influence on GABA-ergic Neurotransmission of 1,2,4-Triazole-3-thione-Based Compounds
por: Plech, Tomasz, et al.
Publicado: (2014)

New 1,3,4-Thiadiazole Derivatives with Anticancer Activity
por: Janowska, Sara, et al.
Publicado: (2022)

Ethoxycarbonylmethyl 3-(4-chlorobenzylidene)dithiocarbazate
por: Tabatabaee, Masoumeh, et al.
Publicado: (2010)

Antibacterial Activity of Fluorobenzoylthiosemicarbazides and Their Cyclic Analogues with 1,2,4-Triazole Scaffold
por: Kosikowska, Urszula, et al.
Publicado: (2020)

Molecular mechanism of action and safety of 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione - a novel anticonvulsant drug candidate
por: Kaproń, Barbara, et al.
Publicado: (2017)

Synthesis and antibacterial activity of new (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid derivatives with thiazolidine-2,4-dione, rhodanine and 2-thiohydantoin moieties
por: Trotsko, Nazar, et al.
Publicado: (2018)

Imidazole-Thiosemicarbazide Derivatives as Potent Anti-Mycobacterium tuberculosis Compounds with Antibiofilm Activity
por: Bekier, Adrian, et al.
Publicado: (2021)

Vaccinium uliginosum and Vaccinium myrtillus—Two Species—One Used as a Functional Food
por: Kopystecka, Agnieszka, et al.
Publicado: (2023)

Synthesis and In Vitro Anti-Toxoplasma gondii Activity of Novel Thiazolidin-4-one Derivatives
por: Trotsko, Nazar, et al.
Publicado: (2019)

Synthesis and in vitro antiproliferative and antibacterial activity of new thiazolidine-2,4-dione derivatives
por: Trotsko, Nazar, et al.
Publicado: (2017)

4-Methyl-1-(4-methylbenzylidene)thiosemicarbazide
por: Li, Yu-Feng
Publicado: (2010)

Influence of Thiazolidine-2,4-Dione Derivatives with Azolidine or Thiosemicarbazone Moieties on Haemophilus spp. Planktonic or Biofilm-Forming Cells
por: Trotsko, Nazar, et al.
Publicado: (2019)

1,2,4-Triazine Sulfonamides: Synthesis by Sulfenamide Intermediates, In Vitro Anticancer Screening, Structural Characterization, and Molecular Docking Study
por: Branowska, Danuta, et al.
Publicado: (2020)

Synthesis and Antibacterial Activity of New Thiazolidine-2,4-dione-Based Chlorophenylthiosemicarbazone Hybrids
por: Trotsko, Nazar, et al.
Publicado: (2018)

Pharmacological and Structure-Activity Relationship Evaluation of 4-aryl-1-Diphenylacetyl(thio)semicarbazides
por: Wujec, Monika, et al.
Publicado: (2014)

1-(Biphenyl-4-ylcarbonyl)-3-(4-nitrophenyl)thiourea
por: Yusof, M. Sukeri M., et al.
Publicado: (2011)

4-[4-(Piperidin-1-yl)piperidin-1-yl]benzonitrile
por: Xu, Guo-bin, et al.
Publicado: (2010)

Ultrasound Promoted Synthesis of Bis(substituted pyrazol-4-ylcarbonyl)-Substituted Thioureas
por: Xiao, Li, et al.
Publicado: (2009)

Visible light-induced photocatalytic C–H ethoxycarbonylmethylation of imidazoheterocycles with ethyl diazoacetate
por: Bhattacharjee, Suvam, et al.
Publicado: (2020)

4-Carbethoxy-1-[4-(N,N-dimethylamino)benzoyl]thiosemicarbazide
por: Bera, Hriday, et al.
Publicado: (2010)

4-Ethyl-1-(4-methylbenzylidene)thiosemicarbazide
por: Li, Yu-Feng, et al.
Publicado: (2010)

1-(4-Methoxybenzylidene)-4-methylthiosemicarbazide
por: Li, Yu-Feng
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_t90ipre1qeaujmq1n93eo912is