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Cytotoxic effect and molecular docking of 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)-thiosemicarbazide—a novel topoisomerase II inhibitor

The preliminary cytotoxic effect of 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)-thiosemicarbazide hydrochloride (1)—a potent topoisomerase II inhibitor—was measured using a MTT assay. It was found that the compound decreased the number of viable cells in both estrogen receptor-positive MCF-7 a...

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Detalles Bibliográficos
Autores principales:	Siwek, Agata, Stączek, Paweł, Wujec, Monika, Bielawski, Krzysztof, Bielawska, Anna, Paneth, Piotr
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2012
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578725/ https://www.ncbi.nlm.nih.gov/pubmed/23187686 http://dx.doi.org/10.1007/s00894-012-1679-6

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