Role of Epigenetics in Chronic Myeloid Leukemia

The efficacy of therapeutic modalities in chronic myeloid leukemia (CML) depends on both genetic and epigenetic mechanisms. This review focuses on epigenetic mechanisms involved in the pathogenesis of CML and in resistance of tumor cells to tyrosine kinase inhibitors leading to the leukemic clone es...

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Detalles Bibliográficos
Autores principales: Machova Polakova, Katerina, Koblihova, Jitka, Stopka, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Current Science Inc. 2013
Materias:
Chronic Leukemias (J Goldman, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578734/
https://www.ncbi.nlm.nih.gov/pubmed/23296408
http://dx.doi.org/10.1007/s11899-012-0152-z
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author Machova Polakova, Katerina
Koblihova, Jitka
Stopka, Tomas
author_facet Machova Polakova, Katerina
Koblihova, Jitka
Stopka, Tomas
author_sort Machova Polakova, Katerina
collection PubMed
description The efficacy of therapeutic modalities in chronic myeloid leukemia (CML) depends on both genetic and epigenetic mechanisms. This review focuses on epigenetic mechanisms involved in the pathogenesis of CML and in resistance of tumor cells to tyrosine kinase inhibitors leading to the leukemic clone escape and propagation. Regulatory events at the levels of gene regulation by transcription factors and microRNAs are discussed in the context of CML pathogenesis and therapeutic modalities.
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spelling pubmed-35787342013-02-26 Role of Epigenetics in Chronic Myeloid Leukemia Machova Polakova, Katerina Koblihova, Jitka Stopka, Tomas Curr Hematol Malig Rep Chronic Leukemias (J Goldman, Section Editor) The efficacy of therapeutic modalities in chronic myeloid leukemia (CML) depends on both genetic and epigenetic mechanisms. This review focuses on epigenetic mechanisms involved in the pathogenesis of CML and in resistance of tumor cells to tyrosine kinase inhibitors leading to the leukemic clone escape and propagation. Regulatory events at the levels of gene regulation by transcription factors and microRNAs are discussed in the context of CML pathogenesis and therapeutic modalities. Current Science Inc. 2013-01-08 2013 /pmc/articles/PMC3578734/ /pubmed/23296408 http://dx.doi.org/10.1007/s11899-012-0152-z Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Chronic Leukemias (J Goldman, Section Editor)
Machova Polakova, Katerina
Koblihova, Jitka
Stopka, Tomas
Role of Epigenetics in Chronic Myeloid Leukemia
title Role of Epigenetics in Chronic Myeloid Leukemia
title_full Role of Epigenetics in Chronic Myeloid Leukemia
title_fullStr Role of Epigenetics in Chronic Myeloid Leukemia
title_full_unstemmed Role of Epigenetics in Chronic Myeloid Leukemia
title_short Role of Epigenetics in Chronic Myeloid Leukemia
title_sort role of epigenetics in chronic myeloid leukemia
topic Chronic Leukemias (J Goldman, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578734/
https://www.ncbi.nlm.nih.gov/pubmed/23296408
http://dx.doi.org/10.1007/s11899-012-0152-z
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AT koblihovajitka roleofepigeneticsinchronicmyeloidleukemia
AT stopkatomas roleofepigeneticsinchronicmyeloidleukemia

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