Single Residue Mutation in Active Site of Serine Acetyltransferase Isoform 3 from Entamoeba histolytica Assists in Partial Regaining of Feedback Inhibition by Cysteine

The cysteine biosynthetic pathway is essential for survival of the protist pathogen Entamoeba histolytica, and functions by producing cysteine for countering oxidative attack during infection in human hosts. Serine acetyltransferase (SAT) and O-acetylserine sulfhydrylase (OASS) are involved in cyste...

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Detalles Bibliográficos
Autores principales: Kumar, Sudhir, Mazumder, Mohit, Dharavath, Sudhaker, Gourinath, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578862/
https://www.ncbi.nlm.nih.gov/pubmed/23437075
http://dx.doi.org/10.1371/journal.pone.0055932

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