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Nutritional Status and Cardiac Autophagy
Autophagy is necessary for the degradation of long-lasting proteins and nonfunctional organelles, and is activated to promote cellular survival. However, overactivation of autophagy may deplete essential molecules and organelles responsible for cellular survival. Lifelong calorie restriction by 40%...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Diabetes Association
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579149/ https://www.ncbi.nlm.nih.gov/pubmed/23441078 http://dx.doi.org/10.4093/dmj.2013.37.1.30 |
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author | Ahn, Jihyun Kim, Jaetaek |
author_facet | Ahn, Jihyun Kim, Jaetaek |
author_sort | Ahn, Jihyun |
collection | PubMed |
description | Autophagy is necessary for the degradation of long-lasting proteins and nonfunctional organelles, and is activated to promote cellular survival. However, overactivation of autophagy may deplete essential molecules and organelles responsible for cellular survival. Lifelong calorie restriction by 40% has been shown to increase the cardiac expression of autophagic markers, which suggests that it may have a cardioprotective effect by decreasing oxidative damage brought on by aging and cardiovascular diseases. Although cardiac autophagy is critical to regulating protein quality and maintaining cellular function and survival, increased or excessive autophagy may have deleterious effects on the heart under some circumstances, including pressure overload-induced heart failure. The importance of autophagy has been shown in nutrient supply and preservation of energy in times of limitation, such as ischemia. Some studies have suggested that a transition from obesity to metabolic syndrome may involve progressive changes in myocardial inflammation, mitochondrial dysfunction, fibrosis, apoptosis, and myocardial autophagy. |
format | Online Article Text |
id | pubmed-3579149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Korean Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-35791492013-02-25 Nutritional Status and Cardiac Autophagy Ahn, Jihyun Kim, Jaetaek Diabetes Metab J Review Autophagy is necessary for the degradation of long-lasting proteins and nonfunctional organelles, and is activated to promote cellular survival. However, overactivation of autophagy may deplete essential molecules and organelles responsible for cellular survival. Lifelong calorie restriction by 40% has been shown to increase the cardiac expression of autophagic markers, which suggests that it may have a cardioprotective effect by decreasing oxidative damage brought on by aging and cardiovascular diseases. Although cardiac autophagy is critical to regulating protein quality and maintaining cellular function and survival, increased or excessive autophagy may have deleterious effects on the heart under some circumstances, including pressure overload-induced heart failure. The importance of autophagy has been shown in nutrient supply and preservation of energy in times of limitation, such as ischemia. Some studies have suggested that a transition from obesity to metabolic syndrome may involve progressive changes in myocardial inflammation, mitochondrial dysfunction, fibrosis, apoptosis, and myocardial autophagy. Korean Diabetes Association 2013-02 2013-02-15 /pmc/articles/PMC3579149/ /pubmed/23441078 http://dx.doi.org/10.4093/dmj.2013.37.1.30 Text en Copyright © 2013 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Ahn, Jihyun Kim, Jaetaek Nutritional Status and Cardiac Autophagy |
title | Nutritional Status and Cardiac Autophagy |
title_full | Nutritional Status and Cardiac Autophagy |
title_fullStr | Nutritional Status and Cardiac Autophagy |
title_full_unstemmed | Nutritional Status and Cardiac Autophagy |
title_short | Nutritional Status and Cardiac Autophagy |
title_sort | nutritional status and cardiac autophagy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579149/ https://www.ncbi.nlm.nih.gov/pubmed/23441078 http://dx.doi.org/10.4093/dmj.2013.37.1.30 |
work_keys_str_mv | AT ahnjihyun nutritionalstatusandcardiacautophagy AT kimjaetaek nutritionalstatusandcardiacautophagy |