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Nutritional Status and Cardiac Autophagy

Autophagy is necessary for the degradation of long-lasting proteins and nonfunctional organelles, and is activated to promote cellular survival. However, overactivation of autophagy may deplete essential molecules and organelles responsible for cellular survival. Lifelong calorie restriction by 40%...

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Detalles Bibliográficos
Autores principales: Ahn, Jihyun, Kim, Jaetaek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579149/
https://www.ncbi.nlm.nih.gov/pubmed/23441078
http://dx.doi.org/10.4093/dmj.2013.37.1.30
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author Ahn, Jihyun
Kim, Jaetaek
author_facet Ahn, Jihyun
Kim, Jaetaek
author_sort Ahn, Jihyun
collection PubMed
description Autophagy is necessary for the degradation of long-lasting proteins and nonfunctional organelles, and is activated to promote cellular survival. However, overactivation of autophagy may deplete essential molecules and organelles responsible for cellular survival. Lifelong calorie restriction by 40% has been shown to increase the cardiac expression of autophagic markers, which suggests that it may have a cardioprotective effect by decreasing oxidative damage brought on by aging and cardiovascular diseases. Although cardiac autophagy is critical to regulating protein quality and maintaining cellular function and survival, increased or excessive autophagy may have deleterious effects on the heart under some circumstances, including pressure overload-induced heart failure. The importance of autophagy has been shown in nutrient supply and preservation of energy in times of limitation, such as ischemia. Some studies have suggested that a transition from obesity to metabolic syndrome may involve progressive changes in myocardial inflammation, mitochondrial dysfunction, fibrosis, apoptosis, and myocardial autophagy.
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spelling pubmed-35791492013-02-25 Nutritional Status and Cardiac Autophagy Ahn, Jihyun Kim, Jaetaek Diabetes Metab J Review Autophagy is necessary for the degradation of long-lasting proteins and nonfunctional organelles, and is activated to promote cellular survival. However, overactivation of autophagy may deplete essential molecules and organelles responsible for cellular survival. Lifelong calorie restriction by 40% has been shown to increase the cardiac expression of autophagic markers, which suggests that it may have a cardioprotective effect by decreasing oxidative damage brought on by aging and cardiovascular diseases. Although cardiac autophagy is critical to regulating protein quality and maintaining cellular function and survival, increased or excessive autophagy may have deleterious effects on the heart under some circumstances, including pressure overload-induced heart failure. The importance of autophagy has been shown in nutrient supply and preservation of energy in times of limitation, such as ischemia. Some studies have suggested that a transition from obesity to metabolic syndrome may involve progressive changes in myocardial inflammation, mitochondrial dysfunction, fibrosis, apoptosis, and myocardial autophagy. Korean Diabetes Association 2013-02 2013-02-15 /pmc/articles/PMC3579149/ /pubmed/23441078 http://dx.doi.org/10.4093/dmj.2013.37.1.30 Text en Copyright © 2013 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Ahn, Jihyun
Kim, Jaetaek
Nutritional Status and Cardiac Autophagy
title Nutritional Status and Cardiac Autophagy
title_full Nutritional Status and Cardiac Autophagy
title_fullStr Nutritional Status and Cardiac Autophagy
title_full_unstemmed Nutritional Status and Cardiac Autophagy
title_short Nutritional Status and Cardiac Autophagy
title_sort nutritional status and cardiac autophagy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579149/
https://www.ncbi.nlm.nih.gov/pubmed/23441078
http://dx.doi.org/10.4093/dmj.2013.37.1.30
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