Cargando…

Inhibition of MDMA-induced increase in cortisol does not prevent acute impairment of verbal memory

BACKGROUND: Ecstasy use is commonly linked with memory deficits in abstinent ecstasy users. Similar impairments are being found during ecstasy intoxication after single doses of ± 3,4 metylenedioxymethamphetamine (MDMA). The concordance of memory impairments during intoxication and abstinence sugges...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuypers, KPC, Torre, R, Farre, M, Pujadas, M, Ramaekers, JG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579237/
https://www.ncbi.nlm.nih.gov/pubmed/22946487
http://dx.doi.org/10.1111/j.1476-5381.2012.02196.x
_version_ 1782260107977949184
author Kuypers, KPC
Torre, R
Farre, M
Pujadas, M
Ramaekers, JG
author_facet Kuypers, KPC
Torre, R
Farre, M
Pujadas, M
Ramaekers, JG
author_sort Kuypers, KPC
collection PubMed
description BACKGROUND: Ecstasy use is commonly linked with memory deficits in abstinent ecstasy users. Similar impairments are being found during ecstasy intoxication after single doses of ± 3,4 metylenedioxymethamphetamine (MDMA). The concordance of memory impairments during intoxication and abstinence suggests a similar neuropharmacological mechanism underlying acute and chronic memory impairments. The mechanism underlying this impairment is to date not known. We hypothesized that cortisol might play an important role in this mechanism as cortisol, implicated in the regulation of memory performance, can be brought out of balance by stressors like MDMA. METHODS: In the present study, we aimed to block the MDMA-induced acute memory defect by giving participants a cortisol synthesis inhibitor (metyrapone) together with a single dose of MDMA. Seventeen polydrug MDMA users entered this placebo-controlled within subject study with four treatment conditions. The treatments consisted of MDMA (75 mg) and metyrapone (750 mg), alone and in combination, and double placebo. Pre-treatment with metyrapone or Placebo occurred 1 h prior to MDMA or Placebo administration. Memory performance was tested at peak drug concentrations by means of several memory tests. Cortisol levels were determined in blood and oral fluid; this served as a control measure to see whether manipulations were effective. RESULTS: Main findings indicated that whereas treatment with metyrapone blocked the expected MDMA-induced increase in cortisol levels in blood, it did not prevent the MDMA-induced memory deficit from happening. CONCLUSION: We therefore conclude that MDMA-induced increments in cortisol concentrations are not related to MDMA-induced memory impairments.
format Online
Article
Text
id pubmed-3579237
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Blackwell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-35792372013-02-25 Inhibition of MDMA-induced increase in cortisol does not prevent acute impairment of verbal memory Kuypers, KPC Torre, R Farre, M Pujadas, M Ramaekers, JG Br J Pharmacol Research Papers BACKGROUND: Ecstasy use is commonly linked with memory deficits in abstinent ecstasy users. Similar impairments are being found during ecstasy intoxication after single doses of ± 3,4 metylenedioxymethamphetamine (MDMA). The concordance of memory impairments during intoxication and abstinence suggests a similar neuropharmacological mechanism underlying acute and chronic memory impairments. The mechanism underlying this impairment is to date not known. We hypothesized that cortisol might play an important role in this mechanism as cortisol, implicated in the regulation of memory performance, can be brought out of balance by stressors like MDMA. METHODS: In the present study, we aimed to block the MDMA-induced acute memory defect by giving participants a cortisol synthesis inhibitor (metyrapone) together with a single dose of MDMA. Seventeen polydrug MDMA users entered this placebo-controlled within subject study with four treatment conditions. The treatments consisted of MDMA (75 mg) and metyrapone (750 mg), alone and in combination, and double placebo. Pre-treatment with metyrapone or Placebo occurred 1 h prior to MDMA or Placebo administration. Memory performance was tested at peak drug concentrations by means of several memory tests. Cortisol levels were determined in blood and oral fluid; this served as a control measure to see whether manipulations were effective. RESULTS: Main findings indicated that whereas treatment with metyrapone blocked the expected MDMA-induced increase in cortisol levels in blood, it did not prevent the MDMA-induced memory deficit from happening. CONCLUSION: We therefore conclude that MDMA-induced increments in cortisol concentrations are not related to MDMA-induced memory impairments. Blackwell Publishing Ltd 2013-02 2013-01-16 /pmc/articles/PMC3579237/ /pubmed/22946487 http://dx.doi.org/10.1111/j.1476-5381.2012.02196.x Text en British Journal of Pharmacology © 2013 The British Pharmacological Society
spellingShingle Research Papers
Kuypers, KPC
Torre, R
Farre, M
Pujadas, M
Ramaekers, JG
Inhibition of MDMA-induced increase in cortisol does not prevent acute impairment of verbal memory
title Inhibition of MDMA-induced increase in cortisol does not prevent acute impairment of verbal memory
title_full Inhibition of MDMA-induced increase in cortisol does not prevent acute impairment of verbal memory
title_fullStr Inhibition of MDMA-induced increase in cortisol does not prevent acute impairment of verbal memory
title_full_unstemmed Inhibition of MDMA-induced increase in cortisol does not prevent acute impairment of verbal memory
title_short Inhibition of MDMA-induced increase in cortisol does not prevent acute impairment of verbal memory
title_sort inhibition of mdma-induced increase in cortisol does not prevent acute impairment of verbal memory
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579237/
https://www.ncbi.nlm.nih.gov/pubmed/22946487
http://dx.doi.org/10.1111/j.1476-5381.2012.02196.x
work_keys_str_mv AT kuyperskpc inhibitionofmdmainducedincreaseincortisoldoesnotpreventacuteimpairmentofverbalmemory
AT torrer inhibitionofmdmainducedincreaseincortisoldoesnotpreventacuteimpairmentofverbalmemory
AT farrem inhibitionofmdmainducedincreaseincortisoldoesnotpreventacuteimpairmentofverbalmemory
AT pujadasm inhibitionofmdmainducedincreaseincortisoldoesnotpreventacuteimpairmentofverbalmemory
AT ramaekersjg inhibitionofmdmainducedincreaseincortisoldoesnotpreventacuteimpairmentofverbalmemory