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Urinary Cystatin C and Tubular Proteinuria Predict Progression of Diabetic Nephropathy
OBJECTIVE: The aim of this study was to evaluate the association of urinary cystatin C, a tubular damage marker, with the progression of type 2 diabetic nephropathy. RESERCH DESIGN AND METHODS: The baseline values of serum and urinary cystatin C were measured as primary parameters and those of urina...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579333/ https://www.ncbi.nlm.nih.gov/pubmed/23093662 http://dx.doi.org/10.2337/dc12-0849 |
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author | Kim, Sang Soo Song, Sang Heon Kim, In Joo Jeon, Yun Kyung Kim, Bo Hyun Kwak, Ihm Soo Lee, Eun Kyung Kim, Yong Ki |
author_facet | Kim, Sang Soo Song, Sang Heon Kim, In Joo Jeon, Yun Kyung Kim, Bo Hyun Kwak, Ihm Soo Lee, Eun Kyung Kim, Yong Ki |
author_sort | Kim, Sang Soo |
collection | PubMed |
description | OBJECTIVE: The aim of this study was to evaluate the association of urinary cystatin C, a tubular damage marker, with the progression of type 2 diabetic nephropathy. RESERCH DESIGN AND METHODS: The baseline values of serum and urinary cystatin C were measured as primary parameters and those of urinary nonalbumin protein (NAP) were measured as secondary parameters. In this prospective observational study, a total of 237 type 2 diabetic patients were followed up for 29 months (13–44 months). RESULTS: Both the urinary cystatin C-to-creatinine ratio (CCR) and NAP-to-creatinine ratio (NAPCR) were significantly different according to the degree of albuminuria. Both markers had strongly positive correlations at baseline. After adjusting for several clinical factors, both urinary CCR and NAPCR had significant associations with the decline of the estimated glomerular filtration rate (eGFR) (r = 0.160, P = 0.021; r = 0.412, P < 0.001, respectively). Urinary CCR had positive correlations with the decline of eGFR in the subpopulation of patients with eGFR ≥60 mL/min/1.73 m(2). In patients with eGFR ≥60 mL/min/1.73 m(2) and normoalbuminuria, only urinary NAPCR showed a significant association with the decline of eGFR; urinary CCR did not. In multivariate regression analysis, the number of patients who progressed to chronic kidney disease stage 3 or greater was higher in those in the upper tertiles of both the urinary levels of cystatin C and NAP than in those in the lower tertiles. CONCLUSIONS: The results of this study suggest that urinary cystatin C and NAP may be predictors of the progression of type 2 diabetic nephropathy. |
format | Online Article Text |
id | pubmed-3579333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-35793332014-03-01 Urinary Cystatin C and Tubular Proteinuria Predict Progression of Diabetic Nephropathy Kim, Sang Soo Song, Sang Heon Kim, In Joo Jeon, Yun Kyung Kim, Bo Hyun Kwak, Ihm Soo Lee, Eun Kyung Kim, Yong Ki Diabetes Care Original Research OBJECTIVE: The aim of this study was to evaluate the association of urinary cystatin C, a tubular damage marker, with the progression of type 2 diabetic nephropathy. RESERCH DESIGN AND METHODS: The baseline values of serum and urinary cystatin C were measured as primary parameters and those of urinary nonalbumin protein (NAP) were measured as secondary parameters. In this prospective observational study, a total of 237 type 2 diabetic patients were followed up for 29 months (13–44 months). RESULTS: Both the urinary cystatin C-to-creatinine ratio (CCR) and NAP-to-creatinine ratio (NAPCR) were significantly different according to the degree of albuminuria. Both markers had strongly positive correlations at baseline. After adjusting for several clinical factors, both urinary CCR and NAPCR had significant associations with the decline of the estimated glomerular filtration rate (eGFR) (r = 0.160, P = 0.021; r = 0.412, P < 0.001, respectively). Urinary CCR had positive correlations with the decline of eGFR in the subpopulation of patients with eGFR ≥60 mL/min/1.73 m(2). In patients with eGFR ≥60 mL/min/1.73 m(2) and normoalbuminuria, only urinary NAPCR showed a significant association with the decline of eGFR; urinary CCR did not. In multivariate regression analysis, the number of patients who progressed to chronic kidney disease stage 3 or greater was higher in those in the upper tertiles of both the urinary levels of cystatin C and NAP than in those in the lower tertiles. CONCLUSIONS: The results of this study suggest that urinary cystatin C and NAP may be predictors of the progression of type 2 diabetic nephropathy. American Diabetes Association 2013-03 2013-02-13 /pmc/articles/PMC3579333/ /pubmed/23093662 http://dx.doi.org/10.2337/dc12-0849 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Kim, Sang Soo Song, Sang Heon Kim, In Joo Jeon, Yun Kyung Kim, Bo Hyun Kwak, Ihm Soo Lee, Eun Kyung Kim, Yong Ki Urinary Cystatin C and Tubular Proteinuria Predict Progression of Diabetic Nephropathy |
title | Urinary Cystatin C and Tubular Proteinuria Predict Progression of Diabetic Nephropathy |
title_full | Urinary Cystatin C and Tubular Proteinuria Predict Progression of Diabetic Nephropathy |
title_fullStr | Urinary Cystatin C and Tubular Proteinuria Predict Progression of Diabetic Nephropathy |
title_full_unstemmed | Urinary Cystatin C and Tubular Proteinuria Predict Progression of Diabetic Nephropathy |
title_short | Urinary Cystatin C and Tubular Proteinuria Predict Progression of Diabetic Nephropathy |
title_sort | urinary cystatin c and tubular proteinuria predict progression of diabetic nephropathy |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579333/ https://www.ncbi.nlm.nih.gov/pubmed/23093662 http://dx.doi.org/10.2337/dc12-0849 |
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