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A virus-like particle vaccine platform elicits heightened and hastened local lung mucosal antibody production after a single dose
We show that a model antigen, ovalbumin (OVA), can be chemically conjugated to the exterior of a small heat shock protein (sHsp) cage that has structural similarities to virus-like particles (VLPs). OVA–sHsp conjugation efficiency was dependent upon the stoichiometry and the length of the small mole...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579574/ https://www.ncbi.nlm.nih.gov/pubmed/22465748 http://dx.doi.org/10.1016/j.vaccine.2012.03.035 |