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The Association between Subclinical Atherosclerosis and Uterine Fibroids
OBJECTIVE(S): To explore the atherogenic hypothesis of uterine fibroids among Chinese women. METHODS: In a case-control study, 335 patients confirmed by ultrasound or hysterectomy surgery and 539 controls were enrolled between October 1, 2009 and April 1, 2012. Unconditional logistic regressions wer...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579803/ https://www.ncbi.nlm.nih.gov/pubmed/23451155 http://dx.doi.org/10.1371/journal.pone.0057089 |
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author | He, Yuan Zeng, Qiang Li, Xiaohui Liu, Baohua Wang, Peiyu |
author_facet | He, Yuan Zeng, Qiang Li, Xiaohui Liu, Baohua Wang, Peiyu |
author_sort | He, Yuan |
collection | PubMed |
description | OBJECTIVE(S): To explore the atherogenic hypothesis of uterine fibroids among Chinese women. METHODS: In a case-control study, 335 patients confirmed by ultrasound or hysterectomy surgery and 539 controls were enrolled between October 1, 2009 and April 1, 2012. Unconditional logistic regressions were used to calculate the odds ratios (ORs) for the associations of subclinical atherogenic and cardiovascular risk parameters with uterine fibroids in the overall case group and hysterectomy-confirmed case group, respectively. RESULTS: Higher level of ankle-brachial index (ABI) was independently associated with increased odds of uterine fibroids. The odds of UF among women in the highest tertile of ABI were 1.88 times higher (95%CI: 1.17, 3.02, P(trend) = 0.008) compared to those in the lowest tertile. The serum concentration of homocysteine was inversely related to fibroids (middle vs. low: OR 0.56, 95%CI: 0.36, 0.85; high vs. low: OR 0.50, 95% CI: 0.32, 0.79; P(trend) = 0.002). In the hysterectomy-confirmed group, an inverse association was suggested between high-density lipoprotein cholesterol (HDL-C) and fibroids (OR 0.46, 95% CI: 0.25, 0.84, P(trend) = 0.014). Moreover, the effect of homocysteine concentration was not observed in this group. CONCLUSION(S): These findings suggest that women with uterine fibroids might have an increased risk of subclinical atherosclerosis. |
format | Online Article Text |
id | pubmed-3579803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35798032013-02-28 The Association between Subclinical Atherosclerosis and Uterine Fibroids He, Yuan Zeng, Qiang Li, Xiaohui Liu, Baohua Wang, Peiyu PLoS One Research Article OBJECTIVE(S): To explore the atherogenic hypothesis of uterine fibroids among Chinese women. METHODS: In a case-control study, 335 patients confirmed by ultrasound or hysterectomy surgery and 539 controls were enrolled between October 1, 2009 and April 1, 2012. Unconditional logistic regressions were used to calculate the odds ratios (ORs) for the associations of subclinical atherogenic and cardiovascular risk parameters with uterine fibroids in the overall case group and hysterectomy-confirmed case group, respectively. RESULTS: Higher level of ankle-brachial index (ABI) was independently associated with increased odds of uterine fibroids. The odds of UF among women in the highest tertile of ABI were 1.88 times higher (95%CI: 1.17, 3.02, P(trend) = 0.008) compared to those in the lowest tertile. The serum concentration of homocysteine was inversely related to fibroids (middle vs. low: OR 0.56, 95%CI: 0.36, 0.85; high vs. low: OR 0.50, 95% CI: 0.32, 0.79; P(trend) = 0.002). In the hysterectomy-confirmed group, an inverse association was suggested between high-density lipoprotein cholesterol (HDL-C) and fibroids (OR 0.46, 95% CI: 0.25, 0.84, P(trend) = 0.014). Moreover, the effect of homocysteine concentration was not observed in this group. CONCLUSION(S): These findings suggest that women with uterine fibroids might have an increased risk of subclinical atherosclerosis. Public Library of Science 2013-02-22 /pmc/articles/PMC3579803/ /pubmed/23451155 http://dx.doi.org/10.1371/journal.pone.0057089 Text en © 2013 He et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article He, Yuan Zeng, Qiang Li, Xiaohui Liu, Baohua Wang, Peiyu The Association between Subclinical Atherosclerosis and Uterine Fibroids |
title | The Association between Subclinical Atherosclerosis and Uterine Fibroids |
title_full | The Association between Subclinical Atherosclerosis and Uterine Fibroids |
title_fullStr | The Association between Subclinical Atherosclerosis and Uterine Fibroids |
title_full_unstemmed | The Association between Subclinical Atherosclerosis and Uterine Fibroids |
title_short | The Association between Subclinical Atherosclerosis and Uterine Fibroids |
title_sort | association between subclinical atherosclerosis and uterine fibroids |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579803/ https://www.ncbi.nlm.nih.gov/pubmed/23451155 http://dx.doi.org/10.1371/journal.pone.0057089 |
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